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Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study.
Crit Care 2006; 10(1):R10CC

Abstract

INTRODUCTION

The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital.

METHODS

Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2).

RESULTS

Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay.

CONCLUSIONS

Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake.

Authors+Show Affiliations

Nutrition and Dietetic Research Group, Imperial College, Hammersmith Hospitals NHS Trust, Du Cane Road, London W12 0HS, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16420657

Citation

Nematy, Mohsen, et al. "Changes in Appetite Related Gut Hormones in Intensive Care Unit Patients: a Pilot Cohort Study." Critical Care (London, England), vol. 10, no. 1, 2006, pp. R10.
Nematy M, O'Flynn JE, Wandrag L, et al. Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study. Crit Care. 2006;10(1):R10.
Nematy, M., O'Flynn, J. E., Wandrag, L., Brynes, A. E., Brett, S. J., Patterson, M., ... Frost, G. S. (2006). Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study. Critical Care (London, England), 10(1), pp. R10.
Nematy M, et al. Changes in Appetite Related Gut Hormones in Intensive Care Unit Patients: a Pilot Cohort Study. Crit Care. 2006;10(1):R10. PubMed PMID: 16420657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study. AU - Nematy,Mohsen, AU - O'Flynn,Jacqui E, AU - Wandrag,Liesl, AU - Brynes,Audrey E, AU - Brett,Stephen J, AU - Patterson,Michael, AU - Ghatei,Mohammad A, AU - Bloom,Stephen R, AU - Frost,Gary S, PY - 2005/08/24/received PY - 2005/11/28/accepted PY - 2006/1/20/pubmed PY - 2006/10/26/medline PY - 2006/1/20/entrez SP - R10 EP - R10 JF - Critical care (London, England) JO - Crit Care VL - 10 IS - 1 N2 - INTRODUCTION: The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital. METHODS: Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2). RESULTS: Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay. CONCLUSIONS: Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake. SN - 1466-609X UR - https://www.unboundmedicine.com/medline/citation/16420657/Changes_in_appetite_related_gut_hormones_in_intensive_care_unit_patients:_a_pilot_cohort_study_ L2 - https://ccforum.biomedcentral.com/articles/10.1186/cc3957 DB - PRIME DP - Unbound Medicine ER -