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Household exposure to pesticides and risk of childhood acute leukaemia.
Occup Environ Med. 2006 Feb; 63(2):131-4.OE

Abstract

OBJECTIVES

To investigate the relation between childhood acute leukaemia and household exposure to pesticides.

METHODS

The study included 280 incident cases of acute leukaemia and 288 controls frequency matched on gender, age, hospital, and ethnic origin. The data were obtained from standardised face to face interviews of the mothers with detailed questions on parental occupational history, home and garden insecticide use, and insecticidal treatment of pediculosis. Odds ratios were estimated using unconditional regression models including the stratification variables parental socioeconomic status and housing characteristics.

RESULTS

Acute leukaemia was observed to be significantly associated with maternal home insecticide use during pregnancy (OR = 1.8, 95% CI 1.2 to 2.8) and during childhood (OR = 1.7, 95% CI 1.1 to 2.4), with garden insecticide use (OR = 2.4, 95% CI 1.3 to 4.3), and fungicide use (OR = 2.5, 95% CI 1.0 to 6.2) during childhood. Insecticidal shampoo treatment of pediculosis was also associated with childhood acute leukaemia (OR = 1.9, 95% CI 1.2 to 3.3).

CONCLUSION

The results reported herein support the hypothesis that various types of insecticide exposure may be a risk factor for childhood acute leukaemia. The observed association with insecticidal shampoo treatment of pediculosis, which has never been investigated before, requires further study.

Authors+Show Affiliations

INSERM, U170, IFR69, Villejuif, France. menegaux@vjf.inserm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16421392

Citation

Menegaux, F, et al. "Household Exposure to Pesticides and Risk of Childhood Acute Leukaemia." Occupational and Environmental Medicine, vol. 63, no. 2, 2006, pp. 131-4.
Menegaux F, Baruchel A, Bertrand Y, et al. Household exposure to pesticides and risk of childhood acute leukaemia. Occup Environ Med. 2006;63(2):131-4.
Menegaux, F., Baruchel, A., Bertrand, Y., Lescoeur, B., Leverger, G., Nelken, B., Sommelet, D., Hémon, D., & Clavel, J. (2006). Household exposure to pesticides and risk of childhood acute leukaemia. Occupational and Environmental Medicine, 63(2), 131-4.
Menegaux F, et al. Household Exposure to Pesticides and Risk of Childhood Acute Leukaemia. Occup Environ Med. 2006;63(2):131-4. PubMed PMID: 16421392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Household exposure to pesticides and risk of childhood acute leukaemia. AU - Menegaux,F, AU - Baruchel,A, AU - Bertrand,Y, AU - Lescoeur,B, AU - Leverger,G, AU - Nelken,B, AU - Sommelet,D, AU - Hémon,D, AU - Clavel,J, PY - 2006/1/20/pubmed PY - 2006/2/1/medline PY - 2006/1/20/entrez SP - 131 EP - 4 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 63 IS - 2 N2 - OBJECTIVES: To investigate the relation between childhood acute leukaemia and household exposure to pesticides. METHODS: The study included 280 incident cases of acute leukaemia and 288 controls frequency matched on gender, age, hospital, and ethnic origin. The data were obtained from standardised face to face interviews of the mothers with detailed questions on parental occupational history, home and garden insecticide use, and insecticidal treatment of pediculosis. Odds ratios were estimated using unconditional regression models including the stratification variables parental socioeconomic status and housing characteristics. RESULTS: Acute leukaemia was observed to be significantly associated with maternal home insecticide use during pregnancy (OR = 1.8, 95% CI 1.2 to 2.8) and during childhood (OR = 1.7, 95% CI 1.1 to 2.4), with garden insecticide use (OR = 2.4, 95% CI 1.3 to 4.3), and fungicide use (OR = 2.5, 95% CI 1.0 to 6.2) during childhood. Insecticidal shampoo treatment of pediculosis was also associated with childhood acute leukaemia (OR = 1.9, 95% CI 1.2 to 3.3). CONCLUSION: The results reported herein support the hypothesis that various types of insecticide exposure may be a risk factor for childhood acute leukaemia. The observed association with insecticidal shampoo treatment of pediculosis, which has never been investigated before, requires further study. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/16421392/Household_exposure_to_pesticides_and_risk_of_childhood_acute_leukaemia_ L2 - https://oem.bmj.com/lookup/pmidlookup?view=long&pmid=16421392 DB - PRIME DP - Unbound Medicine ER -