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Outcome of prosthetic joint infections treated with debridement and retention of components.
Clin Infect Dis 2006; 42(4):471-8CI

Abstract

BACKGROUND

Debridement and retention of the prosthesis represents an attractive surgical modality for treatment of prosthetic joint infection, but risk factors for treatment failure require clarification.

METHODS

We conducted a retrospective cohort analysis of all patients with a prosthetic joint infection who were treated with debridement and retention of the prosthesis at the Mayo Clinic (Rochester, Minnesota) between 1995 and 1999.

RESULTS

Debridement and retention of the prosthesis was the initial treatment modality for 99 episodes of prosthetic joint infection that occurred in 91 patients who presented to the Mayo Clinic during 1995-1999. A total of 32% and 23% of all episodes were due to Staphylococcus aureus and coagulase-negative staphylococci, respectively. The median duration of intravenous antimicrobial therapy was 28 days (range, 1-90 days). Oral antimicrobial suppression was used in 89% of the episodes, for a median duration of 541 days (range, 5-2673 days). Treatment failure occurred in 53 episodes during a median follow-up period of 700 days (range, 1-2779 days). The 2-year survival rate free of treatment failure was 60% (95% confidence interval [CI], 50%-71%). Variables associated with an increased risk of treatment failure in multivariable analysis included the presence of a sinus tract (hazard ratio, 2.84; 95% CI, 1.48-5.44; P = .002) and a duration of symptoms prior to debridement of > or = 8 days (hazard ratio, 1.77; 95% CI, 1.02-3.07; P = .04).

CONCLUSIONS

Debridement and retention of the prosthesis is a common surgical modality at our institution to treat prosthetic joint infection. Risk factors independently associated with treatment failure include the presence of a sinus tract and duration of symptoms prior to debridement of > or = 8 days.

Authors+Show Affiliations

Division of Infectious Diseases, Medical University of South Carolina, Charleston, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16421790

Citation

Marculescu, C E., et al. "Outcome of Prosthetic Joint Infections Treated With Debridement and Retention of Components." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 42, no. 4, 2006, pp. 471-8.
Marculescu CE, Berbari EF, Hanssen AD, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42(4):471-8.
Marculescu, C. E., Berbari, E. F., Hanssen, A. D., Steckelberg, J. M., Harmsen, S. W., Mandrekar, J. N., & Osmon, D. R. (2006). Outcome of prosthetic joint infections treated with debridement and retention of components. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 42(4), pp. 471-8.
Marculescu CE, et al. Outcome of Prosthetic Joint Infections Treated With Debridement and Retention of Components. Clin Infect Dis. 2006 Feb 15;42(4):471-8. PubMed PMID: 16421790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome of prosthetic joint infections treated with debridement and retention of components. AU - Marculescu,C E, AU - Berbari,E F, AU - Hanssen,A D, AU - Steckelberg,J M, AU - Harmsen,S W, AU - Mandrekar,J N, AU - Osmon,D R, Y1 - 2006/01/05/ PY - 2005/04/06/received PY - 2005/09/16/accepted PY - 2006/1/20/pubmed PY - 2006/6/29/medline PY - 2006/1/20/entrez SP - 471 EP - 8 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 42 IS - 4 N2 - BACKGROUND: Debridement and retention of the prosthesis represents an attractive surgical modality for treatment of prosthetic joint infection, but risk factors for treatment failure require clarification. METHODS: We conducted a retrospective cohort analysis of all patients with a prosthetic joint infection who were treated with debridement and retention of the prosthesis at the Mayo Clinic (Rochester, Minnesota) between 1995 and 1999. RESULTS: Debridement and retention of the prosthesis was the initial treatment modality for 99 episodes of prosthetic joint infection that occurred in 91 patients who presented to the Mayo Clinic during 1995-1999. A total of 32% and 23% of all episodes were due to Staphylococcus aureus and coagulase-negative staphylococci, respectively. The median duration of intravenous antimicrobial therapy was 28 days (range, 1-90 days). Oral antimicrobial suppression was used in 89% of the episodes, for a median duration of 541 days (range, 5-2673 days). Treatment failure occurred in 53 episodes during a median follow-up period of 700 days (range, 1-2779 days). The 2-year survival rate free of treatment failure was 60% (95% confidence interval [CI], 50%-71%). Variables associated with an increased risk of treatment failure in multivariable analysis included the presence of a sinus tract (hazard ratio, 2.84; 95% CI, 1.48-5.44; P = .002) and a duration of symptoms prior to debridement of > or = 8 days (hazard ratio, 1.77; 95% CI, 1.02-3.07; P = .04). CONCLUSIONS: Debridement and retention of the prosthesis is a common surgical modality at our institution to treat prosthetic joint infection. Risk factors independently associated with treatment failure include the presence of a sinus tract and duration of symptoms prior to debridement of > or = 8 days. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/16421790/Outcome_of_prosthetic_joint_infections_treated_with_debridement_and_retention_of_components_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/499234 DB - PRIME DP - Unbound Medicine ER -