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Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).
Synapse 2006; 59(5):317-9S

Abstract

Microdialysis cannulas were surgically implanted into the striatum of thyroparathyroidectomized (TX) and sham rats in order to determine differences in dopamine release and core body temperature following MDMA administration. Rats were subsequently treated with MDMA (10 mg/kg, s.c.), and striatal DA levels were monitored at 20 min intervals, as well as core temperature every 30 min. Sham rats responded to MDMA with a characteristic hyperthermic response and significant increases in extracellular dopamine. Conversely, TX rats responded to MDMA with a hypothermic response and failed to demonstrate a similar increase from basal dopamine levels. On the basis of these data, thyroid hormones are not only important in the thermogenic effects of MDMA but also appear to have an auxiliary role in MDMA-induced striatal dopamine release.

Authors+Show Affiliations

Virginia College of Osteopathic Medicine, Virginia Polytechnic Institute and State University, Blacksburg, 24060, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16421905

Citation

Peterson, Andrea L., et al. "Hypothyroidism Alters Striatal Dopamine Release Mediated By 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)." Synapse (New York, N.Y.), vol. 59, no. 5, 2006, pp. 317-9.
Peterson AL, Gilman TL, Banks ML, et al. Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Synapse. 2006;59(5):317-9.
Peterson, A. L., Gilman, T. L., Banks, M. L., & Sprague, J. E. (2006). Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Synapse (New York, N.Y.), 59(5), pp. 317-9.
Peterson AL, et al. Hypothyroidism Alters Striatal Dopamine Release Mediated By 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Synapse. 2006;59(5):317-9. PubMed PMID: 16421905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). AU - Peterson,Andrea L, AU - Gilman,Tracy L, AU - Banks,Matthew L, AU - Sprague,Jon E, PY - 2006/1/20/pubmed PY - 2006/5/26/medline PY - 2006/1/20/entrez SP - 317 EP - 9 JF - Synapse (New York, N.Y.) JO - Synapse VL - 59 IS - 5 N2 - Microdialysis cannulas were surgically implanted into the striatum of thyroparathyroidectomized (TX) and sham rats in order to determine differences in dopamine release and core body temperature following MDMA administration. Rats were subsequently treated with MDMA (10 mg/kg, s.c.), and striatal DA levels were monitored at 20 min intervals, as well as core temperature every 30 min. Sham rats responded to MDMA with a characteristic hyperthermic response and significant increases in extracellular dopamine. Conversely, TX rats responded to MDMA with a hypothermic response and failed to demonstrate a similar increase from basal dopamine levels. On the basis of these data, thyroid hormones are not only important in the thermogenic effects of MDMA but also appear to have an auxiliary role in MDMA-induced striatal dopamine release. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/16421905/Hypothyroidism_alters_striatal_dopamine_release_mediated_by_34_methylenedioxymethamphetamine__MDMA_ecstasy__ L2 - https://doi.org/10.1002/syn.20244 DB - PRIME DP - Unbound Medicine ER -