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Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study.
J Sex Med. 2004 Nov; 1(3):314-7.JS

Abstract

OBJECTIVE

To assess the effect of sildenafil on nocturnal erectile function (EF) in young healthy volunteers with normal sexual function (SF) according to the International Index of Erectile Function (IIEF) questionnaire.

METHODS

Thirty-three young (mean age 21 +/- 0.3 years; range 18-25) healthy volunteers not taking any medications who had normal SF and an EF domain >26 on the IIEF questionnaire were evaluated. Erectile function was assessed using the RigiScan (Dacomed Corp., MN, USA) during three nights: night 1 = adaptation to the NPT-Rigiscan apparatus, night 2 = baseline recording of eight parameters, and night 3 = recordings after ingestion of sildenafil 100 mg. Data on the number of erections, erection duration, minimal and maximal base tumescence, minimal and maximal tip tumescence, and base and tip rigidity were analysed using anova with repeated measures.

RESULTS

A statistically significant improvement in all eight parameters was observed as a result of sildenafil administration: number of erections from 3.1 +/- 0.7 to 4.0 +/- 0.7 (P < 0.05), erection time 22 +/- 3.5 to 34.2 +/- 5.9, minimal base tumescence 8.2 +/- 0.8 to 8.7 +/- 0.8, maximal base tumescence 12.1 +/- 0.7 to 14.2 +/- 0.7, base rigidity 75.6 +/- 3.1 to 81.6 +/- 3.6, tip rigidity 70.6 +/- 1.5 to 75.9 +/- 3.1, minimal tip tumescence 5.9 +/- 0.5 to 6.5 +/- 0.6, and maximal tip tumescence 8.6 +/- 0.6 to 11.7 +/- 0.7 (P < 0.0001 for each of the last seven parameters). The mean sleep duration, 7.3 hours (range 6.30-9.20 hours), was similar for both nights of recording.

CONCLUSIONS

Sildenafil increases the quality and number of nocturnal erections as tested by the NPT-RigiScan in young healthy volunteers with normal EF.

Authors+Show Affiliations

Greenstein A
Department of Urology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel. surge04@post.tau.ac.il
Chen J
No affiliation info available
Salonia A
No affiliation info available
Sofer M
No affiliation info available
Matzkin H
No affiliation info available
Montorsi F
No affiliation info available

MeSH

AdolescentAdultHealth StatusHumansMalePenile ErectionPhosphodiesterase InhibitorsPiperazinesPurinesSildenafil CitrateSulfonesSurveys and QuestionnairesTime Factors

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16422962

Citation

Greenstein, Alexander, et al. "Does Sildenafil Enhance Quality of Nocturnal Erections in Healthy Young Men? a NPT-RigiScan Study." The Journal of Sexual Medicine, vol. 1, no. 3, 2004, pp. 314-7.
Greenstein A, Chen J, Salonia A, et al. Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. J Sex Med. 2004;1(3):314-7.
Greenstein, A., Chen, J., Salonia, A., Sofer, M., Matzkin, H., & Montorsi, F. (2004). Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. The Journal of Sexual Medicine, 1(3), 314-7.
Greenstein A, et al. Does Sildenafil Enhance Quality of Nocturnal Erections in Healthy Young Men? a NPT-RigiScan Study. J Sex Med. 2004;1(3):314-7. PubMed PMID: 16422962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. AU - Greenstein,Alexander, AU - Chen,Juza, AU - Salonia,Andrea, AU - Sofer,Mario, AU - Matzkin,Haim, AU - Montorsi,Francesco, PY - 2006/1/21/pubmed PY - 2006/3/8/medline PY - 2006/1/21/entrez SP - 314 EP - 7 JF - The journal of sexual medicine JO - J Sex Med VL - 1 IS - 3 N2 - OBJECTIVE: To assess the effect of sildenafil on nocturnal erectile function (EF) in young healthy volunteers with normal sexual function (SF) according to the International Index of Erectile Function (IIEF) questionnaire. METHODS: Thirty-three young (mean age 21 +/- 0.3 years; range 18-25) healthy volunteers not taking any medications who had normal SF and an EF domain >26 on the IIEF questionnaire were evaluated. Erectile function was assessed using the RigiScan (Dacomed Corp., MN, USA) during three nights: night 1 = adaptation to the NPT-Rigiscan apparatus, night 2 = baseline recording of eight parameters, and night 3 = recordings after ingestion of sildenafil 100 mg. Data on the number of erections, erection duration, minimal and maximal base tumescence, minimal and maximal tip tumescence, and base and tip rigidity were analysed using anova with repeated measures. RESULTS: A statistically significant improvement in all eight parameters was observed as a result of sildenafil administration: number of erections from 3.1 +/- 0.7 to 4.0 +/- 0.7 (P < 0.05), erection time 22 +/- 3.5 to 34.2 +/- 5.9, minimal base tumescence 8.2 +/- 0.8 to 8.7 +/- 0.8, maximal base tumescence 12.1 +/- 0.7 to 14.2 +/- 0.7, base rigidity 75.6 +/- 3.1 to 81.6 +/- 3.6, tip rigidity 70.6 +/- 1.5 to 75.9 +/- 3.1, minimal tip tumescence 5.9 +/- 0.5 to 6.5 +/- 0.6, and maximal tip tumescence 8.6 +/- 0.6 to 11.7 +/- 0.7 (P < 0.0001 for each of the last seven parameters). The mean sleep duration, 7.3 hours (range 6.30-9.20 hours), was similar for both nights of recording. CONCLUSIONS: Sildenafil increases the quality and number of nocturnal erections as tested by the NPT-RigiScan in young healthy volunteers with normal EF. SN - 1743-6095 UR - https://www.unboundmedicine.com/medline/citation/16422962/Does_sildenafil_enhance_quality_of_nocturnal_erections_in_healthy_young_men_A_NPT_RigiScan_study_ DB - PRIME DP - Unbound Medicine ER -