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Duration of action of sildenafil citrate in men with erectile dysfunction.
J Sex Med. 2004 Sep; 1(2):179-84.JS

Abstract

INTRODUCTION

Viagra (sildenafil citrate) has a rapid onset of action for the treatment of erectile dysfunction (ED). However, its duration of action has not been thoroughly investigated. Practical knowledge of the time window available for sexual intercourse would be valuable for couples planning sexual activity.

AIM

We investigated the duration of action of sildenafil in men with ED.

METHODS

This was a double-blind, randomized, placebo-controlled, four-way crossover study of 16 men, mean age of 55 years (range, 36-68 years) with ED of no known organic cause. Participants received oral sildenafil (100 mg) or placebo 1, 8, or 12 hours before visual sexual stimulation (VSS). Measurements included the duration of erections of >or= 60% rigidity, assessed by penile plethysmography (RigiScan), and the proportion of sildenafil responders, defined as patients with erections of >or= 60% rigidity for >or= 4 minutes and >or= 50% improvement over erections achieved in their placebo arm. Self-assessed duration of grade 3 (hard enough for penetration) or grade 4 (fully hard) erections was also recorded.

RESULTS

At 1, 8, and 12 hours after dosing with sildenafil, the mean duration of erections with >or= 60% rigidity was 26, 11, and 8 minutes, respectively, compared with only 3 minutes after placebo dosing (P < 0.05). However, the mean duration of self-assessed erections was 33, 23, and 16 minutes, respectively, compared with 7 minutes after placebo dosing (P < 0.05), and was greater than that assessed by RigiScan. Of the 69% sildenafil responders at 1 hour, 82% responded at 8 hours and 45% responded at 12 hours after sildenafil administration.

CONCLUSION

Sildenafil improved objective and self-assessed erectile function in men with ED, and the duration of action of sildenafil was longer than that previously reported. These data suggest that sildenafil may be effective in a significant proportion of men with ED up to 12 hours after being taken.

Authors+Show Affiliations

Department of Urology, Southmead Hospital, Westbury-on-Trym, Bristol, UK. clivegingell@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16422972

Citation

Gingell, Clive, et al. "Duration of Action of Sildenafil Citrate in Men With Erectile Dysfunction." The Journal of Sexual Medicine, vol. 1, no. 2, 2004, pp. 179-84.
Gingell C, Sultana SR, Wulff MB, et al. Duration of action of sildenafil citrate in men with erectile dysfunction. J Sex Med. 2004;1(2):179-84.
Gingell, C., Sultana, S. R., Wulff, M. B., & Gepi-Attee, S. (2004). Duration of action of sildenafil citrate in men with erectile dysfunction. The Journal of Sexual Medicine, 1(2), 179-84.
Gingell C, et al. Duration of Action of Sildenafil Citrate in Men With Erectile Dysfunction. J Sex Med. 2004;1(2):179-84. PubMed PMID: 16422972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of action of sildenafil citrate in men with erectile dysfunction. AU - Gingell,Clive, AU - Sultana,Stefan R, AU - Wulff,Maria B, AU - Gepi-Attee,Sam, PY - 2006/1/21/pubmed PY - 2006/7/13/medline PY - 2006/1/21/entrez SP - 179 EP - 84 JF - The journal of sexual medicine JO - J Sex Med VL - 1 IS - 2 N2 - INTRODUCTION: Viagra (sildenafil citrate) has a rapid onset of action for the treatment of erectile dysfunction (ED). However, its duration of action has not been thoroughly investigated. Practical knowledge of the time window available for sexual intercourse would be valuable for couples planning sexual activity. AIM: We investigated the duration of action of sildenafil in men with ED. METHODS: This was a double-blind, randomized, placebo-controlled, four-way crossover study of 16 men, mean age of 55 years (range, 36-68 years) with ED of no known organic cause. Participants received oral sildenafil (100 mg) or placebo 1, 8, or 12 hours before visual sexual stimulation (VSS). Measurements included the duration of erections of >or= 60% rigidity, assessed by penile plethysmography (RigiScan), and the proportion of sildenafil responders, defined as patients with erections of >or= 60% rigidity for >or= 4 minutes and >or= 50% improvement over erections achieved in their placebo arm. Self-assessed duration of grade 3 (hard enough for penetration) or grade 4 (fully hard) erections was also recorded. RESULTS: At 1, 8, and 12 hours after dosing with sildenafil, the mean duration of erections with >or= 60% rigidity was 26, 11, and 8 minutes, respectively, compared with only 3 minutes after placebo dosing (P < 0.05). However, the mean duration of self-assessed erections was 33, 23, and 16 minutes, respectively, compared with 7 minutes after placebo dosing (P < 0.05), and was greater than that assessed by RigiScan. Of the 69% sildenafil responders at 1 hour, 82% responded at 8 hours and 45% responded at 12 hours after sildenafil administration. CONCLUSION: Sildenafil improved objective and self-assessed erectile function in men with ED, and the duration of action of sildenafil was longer than that previously reported. These data suggest that sildenafil may be effective in a significant proportion of men with ED up to 12 hours after being taken. SN - 1743-6095 UR - https://www.unboundmedicine.com/medline/citation/16422972/Duration_of_action_of_sildenafil_citrate_in_men_with_erectile_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)30078-3 DB - PRIME DP - Unbound Medicine ER -