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Stability of Delta(9)-tetrahydrocannabinol (THC) in oral fluid using the Quantisal collection device.
Forensic Sci Int. 2006 Dec 20; 164(2-3):126-30.FS

Abstract

This article details the stability of Delta(9)-tetrahydrocannabinol (THC) in oral fluid during collection, extraction and storage. Oral fluid is being increasingly used as the specimen of choice for the detection of drug use in various applications. Studies to determine the extraction efficiency of THC from the collection buffer and stability under various laboratory storage conditions were carried out. THC was extracted from the collection pad and buffer with an average efficiency over 80% and was stable in Quantisal oral fluid extraction buffer when stored at refrigerated temperatures. Fluorescent lighting caused THC losses of over 50%, however the presence of the pad reduced the loss. In the dark, the loss of THC at room temperature was approximately 20% over 14 days. When stored with the serum separators in place, THC losses were significant. After 3 days, THC concentration was reduced by almost 30%, and after 14 days, 60% of the drug was lost and the losses were not concentration dependent.

Authors+Show Affiliations

Immunalysis Corporation, Pomona, CA 91767, USA. cmoore@immunalysis.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16423482

Citation

Moore, C, et al. "Stability of Delta(9)-tetrahydrocannabinol (THC) in Oral Fluid Using the Quantisal Collection Device." Forensic Science International, vol. 164, no. 2-3, 2006, pp. 126-30.
Moore C, Vincent M, Rana S, et al. Stability of Delta(9)-tetrahydrocannabinol (THC) in oral fluid using the Quantisal collection device. Forensic Sci Int. 2006;164(2-3):126-30.
Moore, C., Vincent, M., Rana, S., Coulter, C., Agrawal, A., & Soares, J. (2006). Stability of Delta(9)-tetrahydrocannabinol (THC) in oral fluid using the Quantisal collection device. Forensic Science International, 164(2-3), 126-30.
Moore C, et al. Stability of Delta(9)-tetrahydrocannabinol (THC) in Oral Fluid Using the Quantisal Collection Device. Forensic Sci Int. 2006 Dec 20;164(2-3):126-30. PubMed PMID: 16423482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of Delta(9)-tetrahydrocannabinol (THC) in oral fluid using the Quantisal collection device. AU - Moore,C, AU - Vincent,M, AU - Rana,S, AU - Coulter,C, AU - Agrawal,A, AU - Soares,J, Y1 - 2006/01/19/ PY - 2005/08/30/received PY - 2005/12/06/revised PY - 2005/12/06/accepted PY - 2006/1/21/pubmed PY - 2007/3/17/medline PY - 2006/1/21/entrez SP - 126 EP - 30 JF - Forensic science international JO - Forensic Sci. Int. VL - 164 IS - 2-3 N2 - This article details the stability of Delta(9)-tetrahydrocannabinol (THC) in oral fluid during collection, extraction and storage. Oral fluid is being increasingly used as the specimen of choice for the detection of drug use in various applications. Studies to determine the extraction efficiency of THC from the collection buffer and stability under various laboratory storage conditions were carried out. THC was extracted from the collection pad and buffer with an average efficiency over 80% and was stable in Quantisal oral fluid extraction buffer when stored at refrigerated temperatures. Fluorescent lighting caused THC losses of over 50%, however the presence of the pad reduced the loss. In the dark, the loss of THC at room temperature was approximately 20% over 14 days. When stored with the serum separators in place, THC losses were significant. After 3 days, THC concentration was reduced by almost 30%, and after 14 days, 60% of the drug was lost and the losses were not concentration dependent. SN - 0379-0738 UR - https://www.unboundmedicine.com/medline/citation/16423482/Stability_of_Delta_9__tetrahydrocannabinol__THC__in_oral_fluid_using_the_Quantisal_collection_device_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(05)00645-6 DB - PRIME DP - Unbound Medicine ER -