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Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients.
Metabolism. 2006 Feb; 55(2):258-62.M

Abstract

The aim of the present study was to investigate the relationships between interleukin 6 (IL-6) and insulin resistance, serum leptin, serum adiponectin, or serum lipids including triglycerides in 98 nonobese Japanese type 2 diabetic patients. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Serum IL-6 concentration was negatively correlated to high-density lipoprotein cholesterol (r = -0.295, P = .004), but was not associated with HOMA-IR (r = 0.016, P = .871), body mass index (BMI) (r = 0.090, P = .375), systolic (r = 0.169, P = .116) and diastolic (r = -0.061, P = .570) blood pressures, leptin (r = 0.062, P = .544), and adiponectin (r = -0.020, P = .841) in these patients. In contrast, serum leptin level was positively correlated to HOMA-IR (r = 0.291, P = .004), BMI (r = 0.338, P < .001), and systolic blood pressure (r = 0.241, P = .025). Serum adiponectin level was negatively correlated to HOMA-IR (r = -0.288, P = .005), BMI (r = -0.308, P = .002), diastolic blood pressure (r = -0.269, P = .012), and triglycerides (r = -0.338, P < .001), and positively correlated to high-density lipoprotein cholesterol (r = 0.300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients.

Authors+Show Affiliations

Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, Osaka 553-0003, Japan. taniguchi.ataru@a5.kepco.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16423635

Citation

Taniguchi, Ataru, et al. "Interleukin 6, Adiponectin, Leptin, and Insulin Resistance in Nonobese Japanese Type 2 Diabetic Patients." Metabolism: Clinical and Experimental, vol. 55, no. 2, 2006, pp. 258-62.
Taniguchi A, Fukushima M, Ohya M, et al. Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. Metab Clin Exp. 2006;55(2):258-62.
Taniguchi, A., Fukushima, M., Ohya, M., Nakai, Y., Yoshii, S., Nagasaka, S., Matsumoto, K., Taki, Y., Kuroe, A., Nishimura, F., & Seino, Y. (2006). Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. Metabolism: Clinical and Experimental, 55(2), 258-62.
Taniguchi A, et al. Interleukin 6, Adiponectin, Leptin, and Insulin Resistance in Nonobese Japanese Type 2 Diabetic Patients. Metab Clin Exp. 2006;55(2):258-62. PubMed PMID: 16423635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. AU - Taniguchi,Ataru, AU - Fukushima,Mitsuo, AU - Ohya,Michihiro, AU - Nakai,Yoshikatsu, AU - Yoshii,Satoru, AU - Nagasaka,Shoichiro, AU - Matsumoto,Kazunari, AU - Taki,Yoshiro, AU - Kuroe,Akira, AU - Nishimura,Fusanori, AU - Seino,Yutaka, PY - 2005/05/07/received PY - 2005/08/23/accepted PY - 2006/1/21/pubmed PY - 2006/3/18/medline PY - 2006/1/21/entrez SP - 258 EP - 62 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 55 IS - 2 N2 - The aim of the present study was to investigate the relationships between interleukin 6 (IL-6) and insulin resistance, serum leptin, serum adiponectin, or serum lipids including triglycerides in 98 nonobese Japanese type 2 diabetic patients. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Serum IL-6 concentration was negatively correlated to high-density lipoprotein cholesterol (r = -0.295, P = .004), but was not associated with HOMA-IR (r = 0.016, P = .871), body mass index (BMI) (r = 0.090, P = .375), systolic (r = 0.169, P = .116) and diastolic (r = -0.061, P = .570) blood pressures, leptin (r = 0.062, P = .544), and adiponectin (r = -0.020, P = .841) in these patients. In contrast, serum leptin level was positively correlated to HOMA-IR (r = 0.291, P = .004), BMI (r = 0.338, P < .001), and systolic blood pressure (r = 0.241, P = .025). Serum adiponectin level was negatively correlated to HOMA-IR (r = -0.288, P = .005), BMI (r = -0.308, P = .002), diastolic blood pressure (r = -0.269, P = .012), and triglycerides (r = -0.338, P < .001), and positively correlated to high-density lipoprotein cholesterol (r = 0.300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16423635/Interleukin_6_adiponectin_leptin_and_insulin_resistance_in_nonobese_Japanese_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(05)00344-6 DB - PRIME DP - Unbound Medicine ER -