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Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma.
Chest 2006; 129(1):39-49Chest

Abstract

BACKGROUND

Previous research has demonstrated that fish oil supplementation has a protective effect on exercise-induced bronchoconstriction (EIB) in elite athletes, which may be attributed to its antiinflammatory properties. Since EIB in asthma involves proinflammatory mediator release, it is feasible that fish oil supplementation may reduce the severity of EIB in asthmatic subjects.

STUDY OBJECTIVES

To determine the efficacy of fish oil supplementation on severity of EIB in subjects with asthma.

DESIGN

Randomized, double-blind, crossover study.

SETTING

Lung function and exercise testing in a university research laboratory.

PATIENTS AND MEASUREMENTS

Sixteen asthmatic patients with documented EIB entered the study on their normal diet and then received either fish oil capsules containing 3.2 g of eicosapentaenoic acid and 2.0 g of docohexaenoic acid (fish oil diet, n = 8) or placebo capsules (placebo diet, n = 8) daily for 3 weeks. At the beginning of the study (normal diet) and at the end of each treatment phase, the following pre-exercise and postexercise measures were assessed: (1) pulmonary function; (2) induced sputum differential cell count percentage and proinflammatory eicosanoid metabolite (leukotriene C4 [LTC4]-leukotriene E4 [LTE4] and prostaglandin D2 [PGD2]) and cytokine (interleukin [IL]-1beta and tumor necrosis factor [TNF]-alpha) concentrations; and (3) eicosanoid metabolites leukotriene B4 (LTB4) and leukotriene B5 (LTB(5)) generation from activated polymorphonuclear leukocytes (PMNLs).

RESULTS

On the normal and placebo diet, subjects exhibited EIB. However, the fish oil diet improved pulmonary function to below the diagnostic EIB threshold, with a concurrent reduction in bronchodilator use. Induced sputum differential cell count percentage and concentrations of LTC4-LTE4, PGD2, IL-1beta, and TNF-alpha were significantly reduced before and following exercise on the fish oil diet compared to the normal and placebo diets. There was a significant reduction in LTB4 and a significant increase in LTB5 generation from activated PMNLs on the fish oil diet compared to the normal and placebo diets.

CONCLUSION

Our data suggest that fish oil supplementation may represent a potentially beneficial nonpharmacologic intervention for asthmatic subjects with EIB.

Authors+Show Affiliations

Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E Seventh St, HPER 112, Bloomington, IN 47401, USA. tmickleb@indiana.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16424411

Citation

Mickleborough, Timothy D., et al. "Protective Effect of Fish Oil Supplementation On Exercise-induced Bronchoconstriction in Asthma." Chest, vol. 129, no. 1, 2006, pp. 39-49.
Mickleborough TD, Lindley MR, Ionescu AA, et al. Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest. 2006;129(1):39-49.
Mickleborough, T. D., Lindley, M. R., Ionescu, A. A., & Fly, A. D. (2006). Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest, 129(1), pp. 39-49.
Mickleborough TD, et al. Protective Effect of Fish Oil Supplementation On Exercise-induced Bronchoconstriction in Asthma. Chest. 2006;129(1):39-49. PubMed PMID: 16424411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. AU - Mickleborough,Timothy D, AU - Lindley,Martin R, AU - Ionescu,Alina A, AU - Fly,Alyce D, PY - 2006/1/21/pubmed PY - 2006/2/17/medline PY - 2006/1/21/entrez SP - 39 EP - 49 JF - Chest JO - Chest VL - 129 IS - 1 N2 - BACKGROUND: Previous research has demonstrated that fish oil supplementation has a protective effect on exercise-induced bronchoconstriction (EIB) in elite athletes, which may be attributed to its antiinflammatory properties. Since EIB in asthma involves proinflammatory mediator release, it is feasible that fish oil supplementation may reduce the severity of EIB in asthmatic subjects. STUDY OBJECTIVES: To determine the efficacy of fish oil supplementation on severity of EIB in subjects with asthma. DESIGN: Randomized, double-blind, crossover study. SETTING: Lung function and exercise testing in a university research laboratory. PATIENTS AND MEASUREMENTS: Sixteen asthmatic patients with documented EIB entered the study on their normal diet and then received either fish oil capsules containing 3.2 g of eicosapentaenoic acid and 2.0 g of docohexaenoic acid (fish oil diet, n = 8) or placebo capsules (placebo diet, n = 8) daily for 3 weeks. At the beginning of the study (normal diet) and at the end of each treatment phase, the following pre-exercise and postexercise measures were assessed: (1) pulmonary function; (2) induced sputum differential cell count percentage and proinflammatory eicosanoid metabolite (leukotriene C4 [LTC4]-leukotriene E4 [LTE4] and prostaglandin D2 [PGD2]) and cytokine (interleukin [IL]-1beta and tumor necrosis factor [TNF]-alpha) concentrations; and (3) eicosanoid metabolites leukotriene B4 (LTB4) and leukotriene B5 (LTB(5)) generation from activated polymorphonuclear leukocytes (PMNLs). RESULTS: On the normal and placebo diet, subjects exhibited EIB. However, the fish oil diet improved pulmonary function to below the diagnostic EIB threshold, with a concurrent reduction in bronchodilator use. Induced sputum differential cell count percentage and concentrations of LTC4-LTE4, PGD2, IL-1beta, and TNF-alpha were significantly reduced before and following exercise on the fish oil diet compared to the normal and placebo diets. There was a significant reduction in LTB4 and a significant increase in LTB5 generation from activated PMNLs on the fish oil diet compared to the normal and placebo diets. CONCLUSION: Our data suggest that fish oil supplementation may represent a potentially beneficial nonpharmacologic intervention for asthmatic subjects with EIB. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/16424411/Protective_effect_of_fish_oil_supplementation_on_exercise_induced_bronchoconstriction_in_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)31520-8 DB - PRIME DP - Unbound Medicine ER -