Tags

Type your tag names separated by a space and hit enter

Osteoporosis in diffuse parenchymal lung disease.
Chest. 2006 Jan; 129(1):140-6.Chest

Abstract

STUDY OBJECTIVES

There are no studies focused on skeletal status in patients with diffuse parenchymal lung disease (DPLD). We hypothesized that patients with DPLD referred for lung transplantation would have a high prevalence of osteoporosis related to corticosteroid use or reduced pulmonary function and exercise capacity.

DESIGN

Retrospective cohort study.

SETTING

Tertiary care center.

PATIENTS

Eighty-six patients with DPLD referred to our center for lung transplantation evaluation between March 1999 and April 2004.

MEASUREMENTS AND RESULTS

Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at the lumbar spine, femoral neck, total hip, and radius at the time of referral. Criteria developed by the World Health Organization were used to define osteopenia and osteoporosis. Fifty-five patients (64%) had usual interstitial pneumonia-pattern lung disease, 14 patients (16%) had nonspecific interstitial pneumonia-pattern lung disease, and 17 patients (20%) had other forms of DPLD. Sixty-four patients (74%) were receiving corticosteroids, and 43 patients (50%) were receiving preventive therapy for osteoporosis. Eleven patients (13%; 95% confidence interval [CI], 7 to 22%) met criteria for osteoporosis at any site, and 49 patients (57%; 95% CI, 46 to 68%) had osteopenia. Lower body mass index (BMI) [adjusted odds ratio (OR), 1.3; 95% CI, 1.1 to 1.6; p = 0.007] and Hispanic ethnicity (adjusted OR, 9.7; 95% CI, 1.8 to 52; p = 0.008) were independently associated with an increased risk of osteoporosis. Linear regression analysis confirmed that BMD at the femoral neck and hip was directly associated with BMI (p < 0.002). These findings were not affected by adjustment for the use of corticosteroids or osteoporosis prophylaxis, pulmonary function, or exercise performance.

CONCLUSIONS

Reduced BMD was common in patients with DPLD who were referred for lung transplantation. Lower BMD was associated with lower BMI, whereas there was no association with other clinical factors in our cohort. Hispanic patients with DPLD had a higher risk of osteoporosis than non-Hispanic patients, independent of other variables. Given their increased risk of bone loss, patients with DPLD should undergo screening for osteoporosis and receive prophylaxis and treatment according to published guidelines.

Authors+Show Affiliations

Department of Medicine, Columbia University College of Physicians and Surgeons, Mount Sinai School of Medicine, New York, NY 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16424424

Citation

Caplan-Shaw, Caralee E., et al. "Osteoporosis in Diffuse Parenchymal Lung Disease." Chest, vol. 129, no. 1, 2006, pp. 140-6.
Caplan-Shaw CE, Arcasoy SM, Shane E, et al. Osteoporosis in diffuse parenchymal lung disease. Chest. 2006;129(1):140-6.
Caplan-Shaw, C. E., Arcasoy, S. M., Shane, E., Lederer, D. J., Wilt, J. S., O'Shea, M. K., Addesso, V., Sonett, J. R., & Kawut, S. M. (2006). Osteoporosis in diffuse parenchymal lung disease. Chest, 129(1), 140-6.
Caplan-Shaw CE, et al. Osteoporosis in Diffuse Parenchymal Lung Disease. Chest. 2006;129(1):140-6. PubMed PMID: 16424424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoporosis in diffuse parenchymal lung disease. AU - Caplan-Shaw,Caralee E, AU - Arcasoy,Selim M, AU - Shane,Elizabeth, AU - Lederer,David J, AU - Wilt,Jessie S, AU - O'Shea,Mitchell K, AU - Addesso,Vicki, AU - Sonett,Joshua R, AU - Kawut,Steven M, PY - 2006/1/21/pubmed PY - 2006/2/17/medline PY - 2006/1/21/entrez SP - 140 EP - 6 JF - Chest JO - Chest VL - 129 IS - 1 N2 - STUDY OBJECTIVES: There are no studies focused on skeletal status in patients with diffuse parenchymal lung disease (DPLD). We hypothesized that patients with DPLD referred for lung transplantation would have a high prevalence of osteoporosis related to corticosteroid use or reduced pulmonary function and exercise capacity. DESIGN: Retrospective cohort study. SETTING: Tertiary care center. PATIENTS: Eighty-six patients with DPLD referred to our center for lung transplantation evaluation between March 1999 and April 2004. MEASUREMENTS AND RESULTS: Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at the lumbar spine, femoral neck, total hip, and radius at the time of referral. Criteria developed by the World Health Organization were used to define osteopenia and osteoporosis. Fifty-five patients (64%) had usual interstitial pneumonia-pattern lung disease, 14 patients (16%) had nonspecific interstitial pneumonia-pattern lung disease, and 17 patients (20%) had other forms of DPLD. Sixty-four patients (74%) were receiving corticosteroids, and 43 patients (50%) were receiving preventive therapy for osteoporosis. Eleven patients (13%; 95% confidence interval [CI], 7 to 22%) met criteria for osteoporosis at any site, and 49 patients (57%; 95% CI, 46 to 68%) had osteopenia. Lower body mass index (BMI) [adjusted odds ratio (OR), 1.3; 95% CI, 1.1 to 1.6; p = 0.007] and Hispanic ethnicity (adjusted OR, 9.7; 95% CI, 1.8 to 52; p = 0.008) were independently associated with an increased risk of osteoporosis. Linear regression analysis confirmed that BMD at the femoral neck and hip was directly associated with BMI (p < 0.002). These findings were not affected by adjustment for the use of corticosteroids or osteoporosis prophylaxis, pulmonary function, or exercise performance. CONCLUSIONS: Reduced BMD was common in patients with DPLD who were referred for lung transplantation. Lower BMD was associated with lower BMI, whereas there was no association with other clinical factors in our cohort. Hispanic patients with DPLD had a higher risk of osteoporosis than non-Hispanic patients, independent of other variables. Given their increased risk of bone loss, patients with DPLD should undergo screening for osteoporosis and receive prophylaxis and treatment according to published guidelines. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/16424424/Osteoporosis_in_diffuse_parenchymal_lung_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)31533-6 DB - PRIME DP - Unbound Medicine ER -