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Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration.
Br J Ophthalmol 2006; 90(2):191-7BJ

Abstract

AIM

To describe the appearance of the non-exudative forms of age related macular degeneration (AMD) as imaged by ultrahigh resolution optical coherence tomography (UHR-OCT).

METHODS

A UHR-OCT ophthalmic imaging system, which utilises a femtosecond laser light source capable of approximately 3 mum axial resolution, was employed to obtain retinal cross sectional images of patients with non-exudative AMD. Observational studies of the resulting retinal images were performed.

RESULTS

52 eyes of 42 patients with the clinical diagnosis of non-exudative AMD were imaged using the UHR-OCT system. 47 of the 52 (90%) eyes had the clinical diagnosis of drusen and/or retinal pigment epithelial (RPE) changes. In these patients, three patterns of drusen were apparent on UHR-OCT: (1) distinct RPE excrescences, (2) a saw toothed pattern of the RPE, and (3) nodular drusen. On UHR-OCT, three eyes (6%) with a clinical diagnosis of non-exudative AMD had evidence of fluid under the retina or RPE. Two of these three patients had findings suspicious for subclinical choroidal neovascularisation on UHR-OCT.

CONCLUSION

With the increased resolution of UHR-OCT compared to standard OCT, the involvement of the outer retinal layers are more clearly defined. UHR-OCT may allow for the detection of early exudative changes not visible clinically or by angiography.

Authors+Show Affiliations

New England Eye Center, Tufts-New England Medical Center, Tufts University, 750 Washington Street, Box 450, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16424532

Citation

Pieroni, C G., et al. "Ultrahigh Resolution Optical Coherence Tomography in Non-exudative Age Related Macular Degeneration." The British Journal of Ophthalmology, vol. 90, no. 2, 2006, pp. 191-7.
Pieroni CG, Witkin AJ, Ko TH, et al. Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration. Br J Ophthalmol. 2006;90(2):191-7.
Pieroni, C. G., Witkin, A. J., Ko, T. H., Fujimoto, J. G., Chan, A., Schuman, J. S., ... Duker, J. S. (2006). Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration. The British Journal of Ophthalmology, 90(2), pp. 191-7.
Pieroni CG, et al. Ultrahigh Resolution Optical Coherence Tomography in Non-exudative Age Related Macular Degeneration. Br J Ophthalmol. 2006;90(2):191-7. PubMed PMID: 16424532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration. AU - Pieroni,C G, AU - Witkin,A J, AU - Ko,T H, AU - Fujimoto,J G, AU - Chan,A, AU - Schuman,J S, AU - Ishikawa,H, AU - Reichel,E, AU - Duker,J S, PY - 2006/1/21/pubmed PY - 2006/2/24/medline PY - 2006/1/21/entrez SP - 191 EP - 7 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 90 IS - 2 N2 - AIM: To describe the appearance of the non-exudative forms of age related macular degeneration (AMD) as imaged by ultrahigh resolution optical coherence tomography (UHR-OCT). METHODS: A UHR-OCT ophthalmic imaging system, which utilises a femtosecond laser light source capable of approximately 3 mum axial resolution, was employed to obtain retinal cross sectional images of patients with non-exudative AMD. Observational studies of the resulting retinal images were performed. RESULTS: 52 eyes of 42 patients with the clinical diagnosis of non-exudative AMD were imaged using the UHR-OCT system. 47 of the 52 (90%) eyes had the clinical diagnosis of drusen and/or retinal pigment epithelial (RPE) changes. In these patients, three patterns of drusen were apparent on UHR-OCT: (1) distinct RPE excrescences, (2) a saw toothed pattern of the RPE, and (3) nodular drusen. On UHR-OCT, three eyes (6%) with a clinical diagnosis of non-exudative AMD had evidence of fluid under the retina or RPE. Two of these three patients had findings suspicious for subclinical choroidal neovascularisation on UHR-OCT. CONCLUSION: With the increased resolution of UHR-OCT compared to standard OCT, the involvement of the outer retinal layers are more clearly defined. UHR-OCT may allow for the detection of early exudative changes not visible clinically or by angiography. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/16424532/Ultrahigh_resolution_optical_coherence_tomography_in_non_exudative_age_related_macular_degeneration_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=16424532 DB - PRIME DP - Unbound Medicine ER -