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Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden).
Cancer Causes Control. 2006 Mar; 17(2):169-80.CC

Abstract

OBJECTIVE

Based on evidence that phytoestrogens may protect against prostate cancer, we evaluated the associations between serum enterolactone concentration or dietary phytoestrogen intake and risk of prostate cancer.

METHODS

In our Swedish population-based case-control study, questionnaire-data were available for 1,499 prostate cancer cases and 1,130 controls, with serum enterolactone levels in a sub-group of 209 cases and 214 controls. Unconditional logistic regression was performed to estimate multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for associations with risk of prostate cancer.

RESULTS

High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The OR comparing the highest to the lowest quartile of intake was 0.74 (95% CI: 0.57-0.95; p-value for trend: 0.01). In contrast, we found no association between dietary intake of total or individual lignans or isoflavonoids and risk of prostate cancer. Intermediate serum levels of enterolactone were associated with a decreased risk of prostate cancer. The ORs comparing increasing quartiles of serum enterolactone concentration to the lowest quartile were, respectively, 0.28 (95% CI: 0.15-0.55), 0.63 (95% CI: 0.35-1.14) and 0.74 (95% CI: 0.41-1.32).

CONCLUSIONS

Our results support the hypothesis that certain foods high in phytoestrogens are associated with a lower risk of prostate cancer.

Authors+Show Affiliations

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden. maria.hedelin@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16425095

Citation

Hedelin, Maria, et al. "Dietary Phytoestrogen, Serum Enterolactone and Risk of Prostate Cancer: the Cancer Prostate Sweden Study (Sweden)." Cancer Causes & Control : CCC, vol. 17, no. 2, 2006, pp. 169-80.
Hedelin M, Klint A, Chang ET, et al. Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden). Cancer Causes Control. 2006;17(2):169-80.
Hedelin, M., Klint, A., Chang, E. T., Bellocco, R., Johansson, J. E., Andersson, S. O., Heinonen, S. M., Adlercreutz, H., Adami, H. O., Grönberg, H., & Bälter, K. A. (2006). Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden). Cancer Causes & Control : CCC, 17(2), 169-80.
Hedelin M, et al. Dietary Phytoestrogen, Serum Enterolactone and Risk of Prostate Cancer: the Cancer Prostate Sweden Study (Sweden). Cancer Causes Control. 2006;17(2):169-80. PubMed PMID: 16425095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden). AU - Hedelin,Maria, AU - Klint,Asa, AU - Chang,Ellen T, AU - Bellocco,Rino, AU - Johansson,Jan-Erik, AU - Andersson,Swen-Olof, AU - Heinonen,Satu-Maarit, AU - Adlercreutz,Herman, AU - Adami,Hans-Olov, AU - Grönberg,Henrik, AU - Bälter,Katarina Augustsson, PY - 2005/02/07/received PY - 2005/09/07/accepted PY - 2006/1/21/pubmed PY - 2006/4/21/medline PY - 2006/1/21/entrez SP - 169 EP - 80 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 17 IS - 2 N2 - OBJECTIVE: Based on evidence that phytoestrogens may protect against prostate cancer, we evaluated the associations between serum enterolactone concentration or dietary phytoestrogen intake and risk of prostate cancer. METHODS: In our Swedish population-based case-control study, questionnaire-data were available for 1,499 prostate cancer cases and 1,130 controls, with serum enterolactone levels in a sub-group of 209 cases and 214 controls. Unconditional logistic regression was performed to estimate multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for associations with risk of prostate cancer. RESULTS: High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The OR comparing the highest to the lowest quartile of intake was 0.74 (95% CI: 0.57-0.95; p-value for trend: 0.01). In contrast, we found no association between dietary intake of total or individual lignans or isoflavonoids and risk of prostate cancer. Intermediate serum levels of enterolactone were associated with a decreased risk of prostate cancer. The ORs comparing increasing quartiles of serum enterolactone concentration to the lowest quartile were, respectively, 0.28 (95% CI: 0.15-0.55), 0.63 (95% CI: 0.35-1.14) and 0.74 (95% CI: 0.41-1.32). CONCLUSIONS: Our results support the hypothesis that certain foods high in phytoestrogens are associated with a lower risk of prostate cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16425095/Dietary_phytoestrogen_serum_enterolactone_and_risk_of_prostate_cancer:_the_cancer_prostate_Sweden_study__Sweden__ L2 - https://doi.org/10.1007/s10552-005-0342-2 DB - PRIME DP - Unbound Medicine ER -