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Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC).

Abstract

We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal.

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    Source

    International journal of cancer 118:12 2006 Jun 15 pg 3133-9

    MeSH

    Adult
    Aged
    Carcinoma, Renal Cell
    Europe
    Feeding Behavior
    Female
    Follow-Up Studies
    Fruit
    Humans
    Incidence
    Kidney Neoplasms
    Life Style
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Sex Distribution
    Sex Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16425278

    Citation

    Weikert, Steffen, et al. "Fruits and Vegetables and Renal Cell Carcinoma: Findings From the European Prospective Investigation Into Cancer and Nutrition (EPIC)." International Journal of Cancer, vol. 118, no. 12, 2006, pp. 3133-9.
    Weikert S, Boeing H, Pischon T, et al. Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer. 2006;118(12):3133-9.
    Weikert, S., Boeing, H., Pischon, T., Olsen, A., Tjonneland, A., Overvad, K., ... Riboli, E. (2006). Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC). International Journal of Cancer, 118(12), pp. 3133-9.
    Weikert S, et al. Fruits and Vegetables and Renal Cell Carcinoma: Findings From the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2006 Jun 15;118(12):3133-9. PubMed PMID: 16425278.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC). AU - Weikert,Steffen, AU - Boeing,Heiner, AU - Pischon,Tobias, AU - Olsen,Anja, AU - Tjonneland,Anne, AU - Overvad,Kim, AU - Becker,Nikolaus, AU - Linseisen,Jacob, AU - Lahmann,Petra H, AU - Arvaniti,Athina, AU - Kassapa,Christina, AU - Trichoupoulou,Antonia, AU - Sieri,Sabina, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - Panico,Salvatore, AU - van Gils,Carla H, AU - Peeters,Petra H M, AU - Bueno-de-Mesquita,H Bas, AU - Büchner,Frederike L, AU - Ljungberg,Börje, AU - Hallmans,Göran, AU - Berglund,Göran, AU - Wirfält,Elisabet, AU - Pera,Guillem, AU - Dorronsoro,Miren, AU - Gurrea,Aurelio Barricarte, AU - Navarro,Carmen, AU - Martinez,Carmen, AU - Quirós,J Ramón, AU - Allen,Naomi, AU - Roddam,Andrew, AU - Bingham,Sheila, AU - Jenab,Mazda, AU - Slimani,Nadia, AU - Norat,Teresa, AU - Riboli,Elio, PY - 2006/1/21/pubmed PY - 2006/5/24/medline PY - 2006/1/21/entrez SP - 3133 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 118 IS - 12 N2 - We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/16425278/Fruits_and_vegetables_and_renal_cell_carcinoma:_findings_from_the_European_prospective_investigation_into_cancer_and_nutrition__EPIC__ L2 - https://doi.org/10.1002/ijc.21765 DB - PRIME DP - Unbound Medicine ER -