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Possible mechanisms of the cancer-preventive activities of green tea.
Mol Nutr Food Res. 2006 Feb; 50(2):170-5.MN

Abstract

The cancer-preventive activities of tea and some tea constituents, such as caffeine and (-)-epigallocatechin-3-gallate (EGCG), have been demonstrated in animal models. The mechanisms of action of the tea constituents have been extensively investigated, but the mechanisms for the cancer-preventive activity of tea are not clearly understood. This chapter discusses some of the reported studies on the green tea polyphenol, EGCG, and the major issues in the interpretation of these data. Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically relevant ones based on the biological importance of the target as well as the effective concentration and whether the reaction can take place in vivo because of the limited bioavailability of EGCG. We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples.

Authors+Show Affiliations

Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. csyang@rci.rutgers.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16425280

Citation

Yang, Chung S., et al. "Possible Mechanisms of the Cancer-preventive Activities of Green Tea." Molecular Nutrition & Food Research, vol. 50, no. 2, 2006, pp. 170-5.
Yang CS, Sang S, Lambert JD, et al. Possible mechanisms of the cancer-preventive activities of green tea. Mol Nutr Food Res. 2006;50(2):170-5.
Yang, C. S., Sang, S., Lambert, J. D., Hou, Z., Ju, J., & Lu, G. (2006). Possible mechanisms of the cancer-preventive activities of green tea. Molecular Nutrition & Food Research, 50(2), 170-5.
Yang CS, et al. Possible Mechanisms of the Cancer-preventive Activities of Green Tea. Mol Nutr Food Res. 2006;50(2):170-5. PubMed PMID: 16425280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible mechanisms of the cancer-preventive activities of green tea. AU - Yang,Chung S, AU - Sang,Shengmin, AU - Lambert,Joshua D, AU - Hou,Zhe, AU - Ju,Jihyeung, AU - Lu,Gang, PY - 2006/1/21/pubmed PY - 2006/4/28/medline PY - 2006/1/21/entrez SP - 170 EP - 5 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 50 IS - 2 N2 - The cancer-preventive activities of tea and some tea constituents, such as caffeine and (-)-epigallocatechin-3-gallate (EGCG), have been demonstrated in animal models. The mechanisms of action of the tea constituents have been extensively investigated, but the mechanisms for the cancer-preventive activity of tea are not clearly understood. This chapter discusses some of the reported studies on the green tea polyphenol, EGCG, and the major issues in the interpretation of these data. Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically relevant ones based on the biological importance of the target as well as the effective concentration and whether the reaction can take place in vivo because of the limited bioavailability of EGCG. We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/16425280/Possible_mechanisms_of_the_cancer_preventive_activities_of_green_tea_ L2 - https://doi.org/10.1002/mnfr.200500105 DB - PRIME DP - Unbound Medicine ER -