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Induction of mononuclear cell infiltration into liver by Japanese herbal medicine.
Drugs Exp Clin Res 2005; 31(5-6):207-14DE

Abstract

Juzen-Taiho-To (JTT) is a Japanese herbal medicine that has been administered mainly to patients weakened by long illness. Currently, it has also been used for cancer patients and showed antitumor effects that have been reported as phagocytosis enhancement, cytokine induction and antibody production. In this study, we examined the effect of oral administration of JTT in mice on the immunological restoration of the liver, especially focused on natural killer (NK) T-cell induction. Mice were grouped to receive JTT or placebo orally for a period of 1, 3 and 7 days. After sacrifice, the liver tissue was fixed, embedded and stained with hematoxylineosin and some antibodies by common staining methods. Transmission electron microscope (TEM) observation was also carried out. Although the JTT-treated mice had the same appearance as the non-JTT-treated mice, their livers were infiltrated by massive mononuclear cells, some of which were aggregated in clusters. Immunohistochemical staining revealed that there was abundant cytokine expression of interleukin (IL)-12 and massive infiltration of mononuclear cells with large granules in the liver of JTT-treated mice. Oral administration of JTT may induce the expression of IL-12 and be followed by immunological restoration such as NK T-cell induction in liver

Authors+Show Affiliations

Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16425977

Citation

Matsuda, T, et al. "Induction of Mononuclear Cell Infiltration Into Liver By Japanese Herbal Medicine." Drugs Under Experimental and Clinical Research, vol. 31, no. 5-6, 2005, pp. 207-14.
Matsuda T, Uzuki M, Uchida T, et al. Induction of mononuclear cell infiltration into liver by Japanese herbal medicine. Drugs Exp Clin Res. 2005;31(5-6):207-14.
Matsuda, T., Uzuki, M., Uchida, T., Nakamura, M., Tai, M., Shiraishi, N., ... Taniguchi, K. (2005). Induction of mononuclear cell infiltration into liver by Japanese herbal medicine. Drugs Under Experimental and Clinical Research, 31(5-6), pp. 207-14.
Matsuda T, et al. Induction of Mononuclear Cell Infiltration Into Liver By Japanese Herbal Medicine. Drugs Exp Clin Res. 2005;31(5-6):207-14. PubMed PMID: 16425977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of mononuclear cell infiltration into liver by Japanese herbal medicine. AU - Matsuda,T, AU - Uzuki,M, AU - Uchida,T, AU - Nakamura,M, AU - Tai,M, AU - Shiraishi,N, AU - Sazaki,N, AU - Yakushiji,F, AU - Tomiyama,J, AU - Suzuki,S, AU - Fujiki,K, AU - Taniguchi,K, PY - 2006/1/24/pubmed PY - 2006/3/28/medline PY - 2006/1/24/entrez SP - 207 EP - 14 JF - Drugs under experimental and clinical research JO - Drugs Exp Clin Res VL - 31 IS - 5-6 N2 - Juzen-Taiho-To (JTT) is a Japanese herbal medicine that has been administered mainly to patients weakened by long illness. Currently, it has also been used for cancer patients and showed antitumor effects that have been reported as phagocytosis enhancement, cytokine induction and antibody production. In this study, we examined the effect of oral administration of JTT in mice on the immunological restoration of the liver, especially focused on natural killer (NK) T-cell induction. Mice were grouped to receive JTT or placebo orally for a period of 1, 3 and 7 days. After sacrifice, the liver tissue was fixed, embedded and stained with hematoxylineosin and some antibodies by common staining methods. Transmission electron microscope (TEM) observation was also carried out. Although the JTT-treated mice had the same appearance as the non-JTT-treated mice, their livers were infiltrated by massive mononuclear cells, some of which were aggregated in clusters. Immunohistochemical staining revealed that there was abundant cytokine expression of interleukin (IL)-12 and massive infiltration of mononuclear cells with large granules in the liver of JTT-treated mice. Oral administration of JTT may induce the expression of IL-12 and be followed by immunological restoration such as NK T-cell induction in liver SN - 0378-6501 UR - https://www.unboundmedicine.com/medline/citation/16425977/Induction_of_mononuclear_cell_infiltration_into_liver_by_Japanese_herbal_medicine_ DB - PRIME DP - Unbound Medicine ER -