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The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population.
Clin Chim Acta. 2006 Apr; 366(1-2):196-203.CC

Abstract

BACKGROUND

Apolipoprotein E (ApoE) locus has consistently shown a significant association with low-density lipoprotein cholesterol (LDL-C). However, its impact on high-density lipoprotein cholesterol (HDL-C) has been highly controversial suggesting that it may be context-dependent. We examined the gene-gene interaction between the common ApoE and the CETP polymorphisms in determining HDL-C concentrations in men and women from the general population.

METHODS

550 unrelated Caucasian subjects were randomly selected from a Mediterranean Region in Spain. Plasma lipids, anthropometric, clinical and lifestyle variables were measured. Common ApoE and CETP-TaqIB polymorphisms were determined.

RESULTS

We have found a gene-gene interaction between and ApoE and the CETP loci in determining HDL-C concentrations. Thus, after adjustment for gender, age, body mass index, tobacco smoking, alcohol consumption, physical exercise and medication, carriers of the E4 allele had lower HDL-C concentrations [mean and (standard error): 40.1 (2.6) mg/dL] than E2 subjects [47.7 (3.2) mg/dL; p=0.019], and even lower than those of the E3 subjects [44.7 (1.4) mg/dL; p=0.042], only if they had the B1B1 genotype. However, mean HDL-C concentrations were higher among those with E4 allele carrying the B2 allele at the CETP gene locus [50.5 (2.3) mg/dL], and lower among E2 subjects carrying the B2 allele [45.5 (2.6) mg/dL]. This interaction was observed in both men and women. This gene-gene interaction remained statistically significant even after additional adjustment for triglycerides.

CONCLUSIONS

The effect of the ApoE polymorphism on HDL-C concentrations depends on the CETP polymorphism, explaining some of the controversial results previously reported for this polymorphism.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain. sorli@uv.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16426594

Citation

Sorlí, José V., et al. "The Effect of the APOE Polymorphism On HDL-C Concentrations Depends On the Cholesterol Ester Transfer Protein Gene Variation in a Southern European Population." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 366, no. 1-2, 2006, pp. 196-203.
Sorlí JV, Corella D, Francés F, et al. The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population. Clin Chim Acta. 2006;366(1-2):196-203.
Sorlí, J. V., Corella, D., Francés, F., Ramírez, J. B., González, J. I., Guillén, M., & Portolés, O. (2006). The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population. Clinica Chimica Acta; International Journal of Clinical Chemistry, 366(1-2), 196-203.
Sorlí JV, et al. The Effect of the APOE Polymorphism On HDL-C Concentrations Depends On the Cholesterol Ester Transfer Protein Gene Variation in a Southern European Population. Clin Chim Acta. 2006;366(1-2):196-203. PubMed PMID: 16426594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population. AU - Sorlí,José V, AU - Corella,Dolores, AU - Francés,Francesc, AU - Ramírez,Judith B, AU - González,José I, AU - Guillén,Marisa, AU - Portolés,Olga, Y1 - 2006/01/19/ PY - 2005/10/05/received PY - 2005/10/05/revised PY - 2005/10/05/accepted PY - 2006/1/24/pubmed PY - 2006/6/10/medline PY - 2006/1/24/entrez SP - 196 EP - 203 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 366 IS - 1-2 N2 - BACKGROUND: Apolipoprotein E (ApoE) locus has consistently shown a significant association with low-density lipoprotein cholesterol (LDL-C). However, its impact on high-density lipoprotein cholesterol (HDL-C) has been highly controversial suggesting that it may be context-dependent. We examined the gene-gene interaction between the common ApoE and the CETP polymorphisms in determining HDL-C concentrations in men and women from the general population. METHODS: 550 unrelated Caucasian subjects were randomly selected from a Mediterranean Region in Spain. Plasma lipids, anthropometric, clinical and lifestyle variables were measured. Common ApoE and CETP-TaqIB polymorphisms were determined. RESULTS: We have found a gene-gene interaction between and ApoE and the CETP loci in determining HDL-C concentrations. Thus, after adjustment for gender, age, body mass index, tobacco smoking, alcohol consumption, physical exercise and medication, carriers of the E4 allele had lower HDL-C concentrations [mean and (standard error): 40.1 (2.6) mg/dL] than E2 subjects [47.7 (3.2) mg/dL; p=0.019], and even lower than those of the E3 subjects [44.7 (1.4) mg/dL; p=0.042], only if they had the B1B1 genotype. However, mean HDL-C concentrations were higher among those with E4 allele carrying the B2 allele at the CETP gene locus [50.5 (2.3) mg/dL], and lower among E2 subjects carrying the B2 allele [45.5 (2.6) mg/dL]. This interaction was observed in both men and women. This gene-gene interaction remained statistically significant even after additional adjustment for triglycerides. CONCLUSIONS: The effect of the ApoE polymorphism on HDL-C concentrations depends on the CETP polymorphism, explaining some of the controversial results previously reported for this polymorphism. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/16426594/The_effect_of_the_APOE_polymorphism_on_HDL_C_concentrations_depends_on_the_cholesterol_ester_transfer_protein_gene_variation_in_a_Southern_European_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(05)00597-8 DB - PRIME DP - Unbound Medicine ER -