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Effects of polyphenolic antioxidants on exercise-induced oxidative stress.
Clin Nutr. 2006 Jun; 25(3):444-53.CN

Abstract

Polyphenols are of increasing interest to consumers and food manufacturers for several reasons. Commonly referred to as antioxidants (they are the most abundant antioxidants in our diets), they may prevent various oxidative stress-related diseases, such as cancer, cardiovascular disease, inflammation and others. Physical activity is known to induce oxidative stress in individuals after intensive exercise. In this study, the effect of the flavonoid contents (which are the most abundant polyphenols) was investigated, as the only antioxidant in a replacement drink designed for sportsmen on various oxidative stress biomarkers after two identical trials of sub-maximal aerobic exercise, in a group of 30 sportsmen. In one of the trials, the cyclists consumed the antioxidant supplement (with 2.3g polyphenols/trial), and in another they consumed a placebo. Blood samples were collected both at rest and after exercise immediately and 45 minutes (min) later, for measurements of plasmatic indices of oxidative stress: lipid oxidation (TBARS), total antioxidant status (TAS); protein oxidation (carbonyl groups, CO) and the lactate dehydrogenase (LDH) and creatine kinase (CK) enzymes for each trial. All values were adjusted for changes in plasma volume. No changes were detected in plasma TAS and LDH after exercise or after the polyphenolic supplement. CK and TBARS increased after exercise in both tests. However, in response to strenuous exercise, the polyphenol-supplemented test showed a smaller increase in plasma TBARS and CK than the placebo test. CO increased by 12% in response to the placebo test, whereas it decreased by 23% in the polyphenol-supplement test. This may indicate that the antioxidant supplement offered protection against exercise-induced oxidative stress.

Authors+Show Affiliations

E.U. Human and Dietetic Nutrition, San Antonio Catholic University, Campus Los Jerónimos, s/n. 30107, Murcia. jmmorillas@pdi.ucam.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16426710

Citation

Morillas-Ruiz, J M., et al. "Effects of Polyphenolic Antioxidants On Exercise-induced Oxidative Stress." Clinical Nutrition (Edinburgh, Scotland), vol. 25, no. 3, 2006, pp. 444-53.
Morillas-Ruiz JM, Villegas García JA, López FJ, et al. Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clin Nutr. 2006;25(3):444-53.
Morillas-Ruiz, J. M., Villegas García, J. A., López, F. J., Vidal-Guevara, M. L., & Zafrilla, P. (2006). Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clinical Nutrition (Edinburgh, Scotland), 25(3), 444-53.
Morillas-Ruiz JM, et al. Effects of Polyphenolic Antioxidants On Exercise-induced Oxidative Stress. Clin Nutr. 2006;25(3):444-53. PubMed PMID: 16426710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of polyphenolic antioxidants on exercise-induced oxidative stress. AU - Morillas-Ruiz,J M, AU - Villegas García,J A, AU - López,F J, AU - Vidal-Guevara,M L, AU - Zafrilla,P, Y1 - 2006/01/19/ PY - 2005/08/01/received PY - 2005/11/04/accepted PY - 2006/1/24/pubmed PY - 2006/12/9/medline PY - 2006/1/24/entrez SP - 444 EP - 53 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 25 IS - 3 N2 - Polyphenols are of increasing interest to consumers and food manufacturers for several reasons. Commonly referred to as antioxidants (they are the most abundant antioxidants in our diets), they may prevent various oxidative stress-related diseases, such as cancer, cardiovascular disease, inflammation and others. Physical activity is known to induce oxidative stress in individuals after intensive exercise. In this study, the effect of the flavonoid contents (which are the most abundant polyphenols) was investigated, as the only antioxidant in a replacement drink designed for sportsmen on various oxidative stress biomarkers after two identical trials of sub-maximal aerobic exercise, in a group of 30 sportsmen. In one of the trials, the cyclists consumed the antioxidant supplement (with 2.3g polyphenols/trial), and in another they consumed a placebo. Blood samples were collected both at rest and after exercise immediately and 45 minutes (min) later, for measurements of plasmatic indices of oxidative stress: lipid oxidation (TBARS), total antioxidant status (TAS); protein oxidation (carbonyl groups, CO) and the lactate dehydrogenase (LDH) and creatine kinase (CK) enzymes for each trial. All values were adjusted for changes in plasma volume. No changes were detected in plasma TAS and LDH after exercise or after the polyphenolic supplement. CK and TBARS increased after exercise in both tests. However, in response to strenuous exercise, the polyphenol-supplemented test showed a smaller increase in plasma TBARS and CK than the placebo test. CO increased by 12% in response to the placebo test, whereas it decreased by 23% in the polyphenol-supplement test. This may indicate that the antioxidant supplement offered protection against exercise-induced oxidative stress. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/16426710/Effects_of_polyphenolic_antioxidants_on_exercise_induced_oxidative_stress_ DB - PRIME DP - Unbound Medicine ER -