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Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1.
Phytomedicine. 2006 Nov; 13(9-10):695-701.P

Abstract

A sulphated polysaccharide (SP-2a) from the brown alga Sargassum patens (Kütz.) Agardh (Sargassaceae) was found to significantly inhibit the in vitro replication of both the acyclovir (ACV)-sensitive and -resistant strains of Herpes simplex virus type 1 (HSV-1), in dose-dependent manners, with 50% inhibitions occurring with 1.5-5.3 microg/ml of the polysaccharide. SP-2a exhibited extracellular virucidal activity only against the ACV-sensitive strains, but not the resistant strain, at the concentration of 100 microg/ml. The strongest antiviral activities against the different strains of HSV-1 were observed when this polysaccharide was present during and after adsorption of the virus to host cells. The inhibitory effect of SP-2a on virus adsorption occurred dose-dependently in all the HSV-1 strains tested, and the adsorption of the ACV-resistant DM2.1 strain was reduced by 81.9% (relative to control) with 4 microg/ml of the polysaccharide. This study clearly demonstrated that the antiviral mode of action of SP-2a is mediated mainly by inhibiting virus attachment to host cells, and this sulphated polysaccharide might have different modes of action against the ACV-sensitive and -resistant strains of HSV-1.

Authors+Show Affiliations

Zhu W
Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, and Laboratory of Lung Cancer Molecular Biology, Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Lane, Sichuan 610041, China.
Chiu LC
No affiliation info available
Ooi VE
No affiliation info available
Chan PK
No affiliation info available
Ang PO
No affiliation info available

MeSH

AcyclovirAdsorptionAntiviral AgentsDose-Response Relationship, DrugDrug Resistance, ViralHerpesvirus 1, HumanPolysaccharidesSargassumVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16427262

Citation

Zhu, W, et al. "Antiviral Property and Mechanisms of a Sulphated Polysaccharide From the Brown Alga Sargassum Patens Against Herpes Simplex Virus Type 1." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 13, no. 9-10, 2006, pp. 695-701.
Zhu W, Chiu LC, Ooi VE, et al. Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1. Phytomedicine. 2006;13(9-10):695-701.
Zhu, W., Chiu, L. C., Ooi, V. E., Chan, P. K., & Ang, P. O. (2006). Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 13(9-10), 695-701.
Zhu W, et al. Antiviral Property and Mechanisms of a Sulphated Polysaccharide From the Brown Alga Sargassum Patens Against Herpes Simplex Virus Type 1. Phytomedicine. 2006;13(9-10):695-701. PubMed PMID: 16427262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1. AU - Zhu,W, AU - Chiu,L C M, AU - Ooi,V E C, AU - Chan,P K S, AU - Ang,P O,Jr Y1 - 2006/01/19/ PY - 2006/1/24/pubmed PY - 2007/2/14/medline PY - 2006/1/24/entrez SP - 695 EP - 701 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 13 IS - 9-10 N2 - A sulphated polysaccharide (SP-2a) from the brown alga Sargassum patens (Kütz.) Agardh (Sargassaceae) was found to significantly inhibit the in vitro replication of both the acyclovir (ACV)-sensitive and -resistant strains of Herpes simplex virus type 1 (HSV-1), in dose-dependent manners, with 50% inhibitions occurring with 1.5-5.3 microg/ml of the polysaccharide. SP-2a exhibited extracellular virucidal activity only against the ACV-sensitive strains, but not the resistant strain, at the concentration of 100 microg/ml. The strongest antiviral activities against the different strains of HSV-1 were observed when this polysaccharide was present during and after adsorption of the virus to host cells. The inhibitory effect of SP-2a on virus adsorption occurred dose-dependently in all the HSV-1 strains tested, and the adsorption of the ACV-resistant DM2.1 strain was reduced by 81.9% (relative to control) with 4 microg/ml of the polysaccharide. This study clearly demonstrated that the antiviral mode of action of SP-2a is mediated mainly by inhibiting virus attachment to host cells, and this sulphated polysaccharide might have different modes of action against the ACV-sensitive and -resistant strains of HSV-1. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/16427262/Antiviral_property_and_mechanisms_of_a_sulphated_polysaccharide_from_the_brown_alga_Sargassum_patens_against_Herpes_simplex_virus_type_1_ DB - PRIME DP - Unbound Medicine ER -