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Evidence of a role for multiple memory systems in behavioral extinction.
Neurobiol Learn Mem. 2006 May; 85(3):289-99.NL

Abstract

The acquisition of learned behavior involves multiple memory systems, and hippocampal system damage impairs cognitive learning while leaving stimulus-response habit learning intact. In view of evidence that extinction also involves new learning, the present experiments examined whether multiple memory systems theory may be applicable to the neural bases of extinction. Adult Long-Evans rats were trained to run in a straight-alley maze for food reward. Twenty-four hours later, rats matched for runway latencies during acquisition received extinction training. In a response extinction condition conducive to habit learning, rats performed a runway approach response to an empty food cup. In a latent extinction condition conducive to cognitive learning, rats were placed at an empty food cup without performing a runway approach response. Prior to daily extinction training, neural activity of the dorsal hippocampus was reversibly inactivated via infusion of bupivacaine (0.75%, 0.5 microl/side). Control rats receiving saline infusions displayed extinction behavior in both the response and latent training conditions. In contrast, rats receiving bupivacaine extinguished normally in the response condition, but did not display latent extinction. The findings (1) confirm that learning underlying extinction of the same overt behavior can occur with or without explicit performance of the previously acquired response, (2) indicate that extinction learning produced by response and latent training procedures can be neuroanatomically dissociated, and (3) suggest that similarly to initial task acquisition, the hippocampus may critically mediate extinction in situations requiring the use of cognitive learning, such as when performance of a previously acquired response habit is prevented.

Authors+Show Affiliations

Department of Psychology, Texas A&M University, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16427329

Citation

Gabriele, Amanda, and Mark G. Packard. "Evidence of a Role for Multiple Memory Systems in Behavioral Extinction." Neurobiology of Learning and Memory, vol. 85, no. 3, 2006, pp. 289-99.
Gabriele A, Packard MG. Evidence of a role for multiple memory systems in behavioral extinction. Neurobiol Learn Mem. 2006;85(3):289-99.
Gabriele, A., & Packard, M. G. (2006). Evidence of a role for multiple memory systems in behavioral extinction. Neurobiology of Learning and Memory, 85(3), 289-99.
Gabriele A, Packard MG. Evidence of a Role for Multiple Memory Systems in Behavioral Extinction. Neurobiol Learn Mem. 2006;85(3):289-99. PubMed PMID: 16427329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of a role for multiple memory systems in behavioral extinction. AU - Gabriele,Amanda, AU - Packard,Mark G, Y1 - 2006/01/19/ PY - 2005/11/01/received PY - 2005/12/05/revised PY - 2005/12/07/accepted PY - 2006/1/24/pubmed PY - 2006/7/11/medline PY - 2006/1/24/entrez SP - 289 EP - 99 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 85 IS - 3 N2 - The acquisition of learned behavior involves multiple memory systems, and hippocampal system damage impairs cognitive learning while leaving stimulus-response habit learning intact. In view of evidence that extinction also involves new learning, the present experiments examined whether multiple memory systems theory may be applicable to the neural bases of extinction. Adult Long-Evans rats were trained to run in a straight-alley maze for food reward. Twenty-four hours later, rats matched for runway latencies during acquisition received extinction training. In a response extinction condition conducive to habit learning, rats performed a runway approach response to an empty food cup. In a latent extinction condition conducive to cognitive learning, rats were placed at an empty food cup without performing a runway approach response. Prior to daily extinction training, neural activity of the dorsal hippocampus was reversibly inactivated via infusion of bupivacaine (0.75%, 0.5 microl/side). Control rats receiving saline infusions displayed extinction behavior in both the response and latent training conditions. In contrast, rats receiving bupivacaine extinguished normally in the response condition, but did not display latent extinction. The findings (1) confirm that learning underlying extinction of the same overt behavior can occur with or without explicit performance of the previously acquired response, (2) indicate that extinction learning produced by response and latent training procedures can be neuroanatomically dissociated, and (3) suggest that similarly to initial task acquisition, the hippocampus may critically mediate extinction in situations requiring the use of cognitive learning, such as when performance of a previously acquired response habit is prevented. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/16427329/Evidence_of_a_role_for_multiple_memory_systems_in_behavioral_extinction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(05)00138-3 DB - PRIME DP - Unbound Medicine ER -