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Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
Phytomedicine. 2006 Feb; 13(3):192-5.P

Abstract

In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the mechanism of its hepatotoxicity, for example interactions with other co-ingested medication, have been postulated. This present study investigated whether pharmacokinetic interactions between kava constituents and alcohol via alcohol dehydrogenase (ADH) inhibition by individual kavalactones might explain its claimed hepatotoxic effects. Four kavalactones, (+/-)-kavain, methysticin, yangonin and desmethoxyyangonin, fail to inhibit ADH in vitro at 1, 10 or 100 microM concentrations.

Authors+Show Affiliations

Faculty of Pharmacy, University of Sydney, NSW, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16428028

Citation

Anke, J, et al. "Kavalactones Fail to Inhibit Alcohol Dehydrogenase in Vitro." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 13, no. 3, 2006, pp. 192-5.
Anke J, Fu S, Ramzan I. Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine. 2006;13(3):192-5.
Anke, J., Fu, S., & Ramzan, I. (2006). Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 13(3), 192-5.
Anke J, Fu S, Ramzan I. Kavalactones Fail to Inhibit Alcohol Dehydrogenase in Vitro. Phytomedicine. 2006;13(3):192-5. PubMed PMID: 16428028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kavalactones fail to inhibit alcohol dehydrogenase in vitro. AU - Anke,J, AU - Fu,S, AU - Ramzan,I, Y1 - 2005/06/28/ PY - 2004/04/19/received PY - 2004/07/28/accepted PY - 2006/1/24/pubmed PY - 2006/4/20/medline PY - 2006/1/24/entrez SP - 192 EP - 5 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 13 IS - 3 N2 - In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the mechanism of its hepatotoxicity, for example interactions with other co-ingested medication, have been postulated. This present study investigated whether pharmacokinetic interactions between kava constituents and alcohol via alcohol dehydrogenase (ADH) inhibition by individual kavalactones might explain its claimed hepatotoxic effects. Four kavalactones, (+/-)-kavain, methysticin, yangonin and desmethoxyyangonin, fail to inhibit ADH in vitro at 1, 10 or 100 microM concentrations. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/16428028/Kavalactones_fail_to_inhibit_alcohol_dehydrogenase_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(05)00118-2 DB - PRIME DP - Unbound Medicine ER -