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p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN).
Histopathology. 2006 Feb; 48(3):268-74.H

Abstract

AIM

To analyse p53 immunoreactivity in 207 biopsy specimens of lichen sclerosus (LS) and "differentiated vulvar intraepithelial neoplasia" (d-VIN), a postulated precursor lesion for LS-associated vulvar squamous cell carcinoma (SCC), which is characterized by atypical basal keratinocyte proliferations with p53+ basal/suprabasal keratinocyte nuclei.

METHODS AND RESULTS

Forty early, 78 classic, 30 hypertrophic vulvar LS, 26 paediatric vulvar and penile LS, 33 vulvar LS-associated SCC and 30 vulvar/penile control specimens were examined for p53 expression and the presence of d-VIN. Nuclear p53 staining was observed in 175/207 LS biopsy specimens. Eighty percent of early and 69% of paediatric LS showed discontinuous/continuous p53 staining in basal keratinocytes. Classic LS showed no p53 staining in 17%, discontinuous basal keratinocyte staining in 20%, continuous basal keratinocyte staining in 58%, basal/suprabasal staining in 5%. Hypertrophic LS revealed basal keratinocyte staining in 32% and basal/suprabasal staining in 61%. p53 staining was associated with sclerosis of blood vessels and dermis, lymphoid infiltrates, vasculitis and hypertrophic LS. d-VIN was seen in 2% of LS alone and in 24% of LS-associated SCC.

CONCLUSION

d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS.

Authors+Show Affiliations

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16430473

Citation

Liegl, B, and S Regauer. "P53 Immunostaining in Lichen Sclerosus Is Related to Ischaemic Stress and Is Not a Marker of Differentiated Vulvar Intraepithelial Neoplasia (d-VIN)." Histopathology, vol. 48, no. 3, 2006, pp. 268-74.
Liegl B, Regauer S. P53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN). Histopathology. 2006;48(3):268-74.
Liegl, B., & Regauer, S. (2006). P53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN). Histopathology, 48(3), 268-74.
Liegl B, Regauer S. P53 Immunostaining in Lichen Sclerosus Is Related to Ischaemic Stress and Is Not a Marker of Differentiated Vulvar Intraepithelial Neoplasia (d-VIN). Histopathology. 2006;48(3):268-74. PubMed PMID: 16430473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN). AU - Liegl,B, AU - Regauer,S, PY - 2006/1/25/pubmed PY - 2006/3/17/medline PY - 2006/1/25/entrez SP - 268 EP - 74 JF - Histopathology JO - Histopathology VL - 48 IS - 3 N2 - AIM: To analyse p53 immunoreactivity in 207 biopsy specimens of lichen sclerosus (LS) and "differentiated vulvar intraepithelial neoplasia" (d-VIN), a postulated precursor lesion for LS-associated vulvar squamous cell carcinoma (SCC), which is characterized by atypical basal keratinocyte proliferations with p53+ basal/suprabasal keratinocyte nuclei. METHODS AND RESULTS: Forty early, 78 classic, 30 hypertrophic vulvar LS, 26 paediatric vulvar and penile LS, 33 vulvar LS-associated SCC and 30 vulvar/penile control specimens were examined for p53 expression and the presence of d-VIN. Nuclear p53 staining was observed in 175/207 LS biopsy specimens. Eighty percent of early and 69% of paediatric LS showed discontinuous/continuous p53 staining in basal keratinocytes. Classic LS showed no p53 staining in 17%, discontinuous basal keratinocyte staining in 20%, continuous basal keratinocyte staining in 58%, basal/suprabasal staining in 5%. Hypertrophic LS revealed basal keratinocyte staining in 32% and basal/suprabasal staining in 61%. p53 staining was associated with sclerosis of blood vessels and dermis, lymphoid infiltrates, vasculitis and hypertrophic LS. d-VIN was seen in 2% of LS alone and in 24% of LS-associated SCC. CONCLUSION: d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/16430473/p53_immunostaining_in_lichen_sclerosus_is_related_to_ischaemic_stress_and_is_not_a_marker_of_differentiated_vulvar_intraepithelial_neoplasia__d_VIN__ L2 - https://doi.org/10.1111/j.1365-2559.2005.02321.x DB - PRIME DP - Unbound Medicine ER -