Tags

Type your tag names separated by a space and hit enter

Developing therapeutics for the diseases of protein misfolding.
Neurology 2006; 66(2 Suppl 1):S118-22Neur

Abstract

Our current structural and biologic understanding of the misfolding diseases has restricted the development of therapies that target these diseases at a molecular level. The prion diseases are illustrative of this group of misfolding disorders and provide a model system for therapeutic intervention. Strategies to inhibit the replication and accumulation of the prion protein are being developed and have entered animal and clinical studies. Due to the underlying molecular basis of this disease class, many of the therapeutic approaches used to target prion misfolding have parallels in other misfolding diseases.

Authors+Show Affiliations

Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143-2240, USA. alchemi@itsa.ucsf.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16432139

Citation

May, Barnaby C H., et al. "Developing Therapeutics for the Diseases of Protein Misfolding." Neurology, vol. 66, no. 2 Suppl 1, 2006, pp. S118-22.
May BC, Govaerts C, Cohen FE. Developing therapeutics for the diseases of protein misfolding. Neurology. 2006;66(2 Suppl 1):S118-22.
May, B. C., Govaerts, C., & Cohen, F. E. (2006). Developing therapeutics for the diseases of protein misfolding. Neurology, 66(2 Suppl 1), pp. S118-22.
May BC, Govaerts C, Cohen FE. Developing Therapeutics for the Diseases of Protein Misfolding. Neurology. 2006 Jan 24;66(2 Suppl 1):S118-22. PubMed PMID: 16432139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developing therapeutics for the diseases of protein misfolding. AU - May,Barnaby C H, AU - Govaerts,Cedric, AU - Cohen,Fred E, PY - 2006/1/25/pubmed PY - 2006/3/10/medline PY - 2006/1/25/entrez SP - S118 EP - 22 JF - Neurology JO - Neurology VL - 66 IS - 2 Suppl 1 N2 - Our current structural and biologic understanding of the misfolding diseases has restricted the development of therapies that target these diseases at a molecular level. The prion diseases are illustrative of this group of misfolding disorders and provide a model system for therapeutic intervention. Strategies to inhibit the replication and accumulation of the prion protein are being developed and have entered animal and clinical studies. Due to the underlying molecular basis of this disease class, many of the therapeutic approaches used to target prion misfolding have parallels in other misfolding diseases. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16432139/Developing_therapeutics_for_the_diseases_of_protein_misfolding_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16432139 DB - PRIME DP - Unbound Medicine ER -