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Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome.
Ann Surg. 2006 Feb; 243(2):223-8.AnnS

Abstract

OBJECTIVE/SUMMARY BACKGROUND DATA: Serial transverse enteroplasty (STEP) is a new intestinal lengthening procedure that has been shown to clinically increase bowel length. This study examined the impact of the STEP procedure upon intestinal function in a model of short bowel syndrome.

METHODS

Young pigs (n=10) had a reversed segment of bowel interposed to induce bowel dilatation. Five pigs underwent a 90% bowel resection with a STEP procedure on the remaining dilated bowel while 5 served as controls and had a 90% bowel resection without a STEP procedure. Determinations of nutritional status, absorptive capacity, and bacterial overgrowth were conducted 6 weeks after resection. Statistical comparisons were made by 2-sample t test (significance at P<0.05).

RESULTS

The STEP procedure lengthened the bowel from 105.2+/-7.7 cm to 152.2+/-8.3 cm (P<0.01). The STEP animals showed improved weight retention compared with controls (mean, -0.5%+/-1.8% body weight versus -17.6%+/-1.5%, P<0.001). Intestinal carbohydrate absorption, as measured by d-Xylose absorption and fat absorptive capacity as measured by serum vitamin D and triglyceride levels, were increased in the STEP group versus controls. Serum citrulline, a marker of intestinal mucosal mass, was significantly elevated in the STEP pigs compared with controls. None of the STEP animals but 4 of 5 control animals were noted to have gram-negative bacterial overgrowth in the proximal bowel.

CONCLUSIONS

STEP improves weight retention, nutritional status, intestinal absorptive capacity, and serum citrulline levels in a porcine short bowel model. A salutary effect upon bacterial overgrowth was also noted. These data support the use of this operation in short bowel syndrome.

Authors+Show Affiliations

Department of Surgery, Children's Hospital Boston and the Harvard Center for Minimally Invasive Surgery, Harvard Medical School, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16432355

Citation

Chang, Robert W., et al. "Serial Transverse Enteroplasty Enhances Intestinal Function in a Model of Short Bowel Syndrome." Annals of Surgery, vol. 243, no. 2, 2006, pp. 223-8.
Chang RW, Javid PJ, Oh JT, et al. Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome. Ann Surg. 2006;243(2):223-8.
Chang, R. W., Javid, P. J., Oh, J. T., Andreoli, S., Kim, H. B., Fauza, D., & Jaksic, T. (2006). Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome. Annals of Surgery, 243(2), 223-8.
Chang RW, et al. Serial Transverse Enteroplasty Enhances Intestinal Function in a Model of Short Bowel Syndrome. Ann Surg. 2006;243(2):223-8. PubMed PMID: 16432355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome. AU - Chang,Robert W, AU - Javid,Patrick J, AU - Oh,Jung-Tak, AU - Andreoli,Steven, AU - Kim,Heung Bae, AU - Fauza,Dario, AU - Jaksic,Tom, PY - 2006/1/25/pubmed PY - 2006/3/17/medline PY - 2006/1/25/entrez SP - 223 EP - 8 JF - Annals of surgery JO - Ann Surg VL - 243 IS - 2 N2 - UNLABELLED: OBJECTIVE/SUMMARY BACKGROUND DATA: Serial transverse enteroplasty (STEP) is a new intestinal lengthening procedure that has been shown to clinically increase bowel length. This study examined the impact of the STEP procedure upon intestinal function in a model of short bowel syndrome. METHODS: Young pigs (n=10) had a reversed segment of bowel interposed to induce bowel dilatation. Five pigs underwent a 90% bowel resection with a STEP procedure on the remaining dilated bowel while 5 served as controls and had a 90% bowel resection without a STEP procedure. Determinations of nutritional status, absorptive capacity, and bacterial overgrowth were conducted 6 weeks after resection. Statistical comparisons were made by 2-sample t test (significance at P<0.05). RESULTS: The STEP procedure lengthened the bowel from 105.2+/-7.7 cm to 152.2+/-8.3 cm (P<0.01). The STEP animals showed improved weight retention compared with controls (mean, -0.5%+/-1.8% body weight versus -17.6%+/-1.5%, P<0.001). Intestinal carbohydrate absorption, as measured by d-Xylose absorption and fat absorptive capacity as measured by serum vitamin D and triglyceride levels, were increased in the STEP group versus controls. Serum citrulline, a marker of intestinal mucosal mass, was significantly elevated in the STEP pigs compared with controls. None of the STEP animals but 4 of 5 control animals were noted to have gram-negative bacterial overgrowth in the proximal bowel. CONCLUSIONS: STEP improves weight retention, nutritional status, intestinal absorptive capacity, and serum citrulline levels in a porcine short bowel model. A salutary effect upon bacterial overgrowth was also noted. These data support the use of this operation in short bowel syndrome. SN - 0003-4932 UR - https://www.unboundmedicine.com/medline/citation/16432355/Serial_transverse_enteroplasty_enhances_intestinal_function_in_a_model_of_short_bowel_syndrome_ L2 - https://doi.org/10.1097/01.sla.0000197704.76166.07 DB - PRIME DP - Unbound Medicine ER -