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Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan.
Int J Obes (Lond). 2006 Jun; 30(6):912-7.IJ

Abstract

OBJECTIVE

To investigate the relationship between the metabolic syndrome and its related factors among non-diabetic pre- and post-menopausal women in North Taiwan.

DESIGN

A cross-sectional study in a medical center in North Taiwan.

SUBJECTS

Five hundred and ninety-four, non-diabetic middle-aged women (age range=40-64 years, mean=48.9+/-5.4 years) were recruited.

MEASUREMENTS

The fasting plasma glucose, insulin, lipids levels and anthropometric indices were measured. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMA-IR). Metabolic syndrome was defined by using the National Cholesterol Education Panel (NCEP) criteria and modified NCEP criteria (waist circumference >80 cm).

RESULTS

The prevalence of metabolic syndrome was 6.2% using NCEP criteria, and 8.9% using modified NCEP criteria. Post-menopausal women had a higher prevalence of metabolic syndrome and its individual components compared to pre-menopausal women except hyperglycemia and low HDL-C. In multiple logistic regression analysis with adjustment for age and menopausal status, both BMI and HOMA-IR were independently associated with the metabolic syndrome.

CONCLUSION

The prevalence of metabolic syndrome was higher in post-menopausal than pre-menopausal women. Both obesity and insulin resistance may play an important role in the development of metabolic syndrome among the middle-aged women in North Taiwan.

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Authors+Show Affiliations

Lin WY
Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yang WS
No affiliation info available
Lee LT
No affiliation info available
Chen CY
No affiliation info available
Liu CS
No affiliation info available
Lin CC
No affiliation info available
Huang KC
No affiliation info available

MeSH

AdultAnthropometryAsian Continental Ancestry GroupBlood GlucoseBlood PressureBody Mass IndexCross-Sectional StudiesDiabetes ComplicationsFemaleHumansInsulinInsulin ResistanceLipidsMetabolic SyndromeMiddle AgedObesityPostmenopausePremenopausePrevalenceTaiwan

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16432538

Citation

Lin, W-Y, et al. "Insulin Resistance, Obesity, and Metabolic Syndrome Among Non-diabetic Pre- and Post-menopausal Women in North Taiwan." International Journal of Obesity (2005), vol. 30, no. 6, 2006, pp. 912-7.
Lin WY, Yang WS, Lee LT, et al. Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan. Int J Obes (Lond). 2006;30(6):912-7.
Lin, W. Y., Yang, W. S., Lee, L. T., Chen, C. Y., Liu, C. S., Lin, C. C., & Huang, K. C. (2006). Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan. International Journal of Obesity (2005), 30(6), 912-7.
Lin WY, et al. Insulin Resistance, Obesity, and Metabolic Syndrome Among Non-diabetic Pre- and Post-menopausal Women in North Taiwan. Int J Obes (Lond). 2006;30(6):912-7. PubMed PMID: 16432538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan. AU - Lin,W-Y, AU - Yang,W-S, AU - Lee,L-T, AU - Chen,C-Y, AU - Liu,C-S, AU - Lin,C-C, AU - Huang,K-C, PY - 2006/1/25/pubmed PY - 2007/1/16/medline PY - 2006/1/25/entrez SP - 912 EP - 7 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 6 N2 - OBJECTIVE: To investigate the relationship between the metabolic syndrome and its related factors among non-diabetic pre- and post-menopausal women in North Taiwan. DESIGN: A cross-sectional study in a medical center in North Taiwan. SUBJECTS: Five hundred and ninety-four, non-diabetic middle-aged women (age range=40-64 years, mean=48.9+/-5.4 years) were recruited. MEASUREMENTS: The fasting plasma glucose, insulin, lipids levels and anthropometric indices were measured. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMA-IR). Metabolic syndrome was defined by using the National Cholesterol Education Panel (NCEP) criteria and modified NCEP criteria (waist circumference >80 cm). RESULTS: The prevalence of metabolic syndrome was 6.2% using NCEP criteria, and 8.9% using modified NCEP criteria. Post-menopausal women had a higher prevalence of metabolic syndrome and its individual components compared to pre-menopausal women except hyperglycemia and low HDL-C. In multiple logistic regression analysis with adjustment for age and menopausal status, both BMI and HOMA-IR were independently associated with the metabolic syndrome. CONCLUSION: The prevalence of metabolic syndrome was higher in post-menopausal than pre-menopausal women. Both obesity and insulin resistance may play an important role in the development of metabolic syndrome among the middle-aged women in North Taiwan. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16432538/Insulin_resistance_obesity_and_metabolic_syndrome_among_non_diabetic_pre__and_post_menopausal_women_in_North_Taiwan_ L2 - https://doi.org/10.1038/sj.ijo.0803240 DB - PRIME DP - Unbound Medicine ER -