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Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly.

Abstract

Splenic volume and Helicobacter pylori (H. pylori) infection were evaluated in 67 patients with chronic idiopathic neutropenia (CIN) and 39 healthy individuals. Using ultrasound, splenomegaly was found in 61.7% of H. pylori-infected subjects compared to only 8.7% noted in the group of H. pylori-non-infected individuals (P < 0.0001). Splenomegaly was also found in 47.8% of CIN patients compared to 12.8% in the group of non-CIN subjects (P = 0.0003). However, applying the two-way ANOVA test, a statistically significant effect on splenic volume was documented for "factor H. pylori " (F1(102) = 16.800, P < 0.0001) but not for "factor CIN" (F1(102) = 3.213, P = 0.0760), suggesting that CIN-associated splenomegaly is probably due to H. pylori infection.

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  • Authors+Show Affiliations

    ,

    Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece. epapadak@med.uoc.gr

    , , , ,

    Source

    American journal of hematology 81:2 2006 Feb pg 142-4

    MeSH

    Adult
    Aged
    Analysis of Variance
    Chronic Disease
    Female
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Male
    Middle Aged
    Neutropenia
    Splenomegaly
    Ultrasonography

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16432851

    Citation

    Papadaki, Helen A., et al. "Helicobacter Pylori Infection Is Probably the Cause of Chronic Idiopathic Neutropenia (CIN)-associated Splenomegaly." American Journal of Hematology, vol. 81, no. 2, 2006, pp. 142-4.
    Papadaki HA, Pontikoglou C, Eliopoulos DG, et al. Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. Am J Hematol. 2006;81(2):142-4.
    Papadaki, H. A., Pontikoglou, C., Eliopoulos, D. G., Pyrovolaki, K., Spyridaki, R., & Eliopoulos, G. D. (2006). Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. American Journal of Hematology, 81(2), pp. 142-4.
    Papadaki HA, et al. Helicobacter Pylori Infection Is Probably the Cause of Chronic Idiopathic Neutropenia (CIN)-associated Splenomegaly. Am J Hematol. 2006;81(2):142-4. PubMed PMID: 16432851.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. AU - Papadaki,Helen A, AU - Pontikoglou,Charis, AU - Eliopoulos,Dimitris G, AU - Pyrovolaki,Katerina, AU - Spyridaki,Rania, AU - Eliopoulos,George D, PY - 2006/1/25/pubmed PY - 2006/4/15/medline PY - 2006/1/25/entrez SP - 142 EP - 4 JF - American journal of hematology JO - Am. J. Hematol. VL - 81 IS - 2 N2 - Splenic volume and Helicobacter pylori (H. pylori) infection were evaluated in 67 patients with chronic idiopathic neutropenia (CIN) and 39 healthy individuals. Using ultrasound, splenomegaly was found in 61.7% of H. pylori-infected subjects compared to only 8.7% noted in the group of H. pylori-non-infected individuals (P < 0.0001). Splenomegaly was also found in 47.8% of CIN patients compared to 12.8% in the group of non-CIN subjects (P = 0.0003). However, applying the two-way ANOVA test, a statistically significant effect on splenic volume was documented for "factor H. pylori " (F1(102) = 16.800, P < 0.0001) but not for "factor CIN" (F1(102) = 3.213, P = 0.0760), suggesting that CIN-associated splenomegaly is probably due to H. pylori infection. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/16432851/Helicobacter_pylori_infection_is_probably_the_cause_of_chronic_idiopathic_neutropenia__CIN__associated_splenomegaly_ L2 - https://doi.org/10.1002/ajh.20496 DB - PRIME DP - Unbound Medicine ER -