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Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology.
Natl Med J India. 2005 Sep-Oct; 18(5):244-6.NM

Abstract

BACKGROUND

Leptospirosis is one of the common zoonoses but, in most instances, the infection goes unnoticed. Rapid diagnostic modalities are needed to diagnose the disease in the early stages. We assessed the usefulness of clinical criteria and compared these with enzyme-linked immunosorbentassay (ELISA) for the early detection of leptospirosis.

METHODS

One hundred patients with a febrile illness for > 7 days were screened by Faine criteria and their sera were subjected to both IgM and IgG ELISA using a commercially available kit (Institut Virion Serion GmbH, Warburg, Germany).

RESULTS

Twenty-six patients satisfied the clinical criteria for leptospirosis and 8 of them tested positive for IgM antibodies while 1 patient who was clinically negative tested positive by serology. Thus, Faine criteria had a sensitivity of 88.9%, specificity of 80.2%, positive predictive value of 30.8% and a negative predictive value of 98.6%. Paired serum samples were obtained from 70 patients but the IgG levels of only 2 showed a 4-fold rise.

CONCLUSION

Faine criteria has moderate sensitivity and specificity but a high negative predictive value in comparison with IgM ELISA. The high negative predictive value may help to screen patients with acute febrile illness for leptospirosis during the early phase of the disease.

Authors+Show Affiliations

Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16433137

Citation

Rao, P, et al. "Screening of Patients With Acute Febrile Illness for Leptospirosis Using Clinical Criteria and Serology." The National Medical Journal of India, vol. 18, no. 5, 2005, pp. 244-6.
Rao P, Sethi S, Sud A, et al. Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology. Natl Med J India. 2005;18(5):244-6.
Rao, P., Sethi, S., Sud, A., Banga, S. S., & Sharma, M. (2005). Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology. The National Medical Journal of India, 18(5), 244-6.
Rao P, et al. Screening of Patients With Acute Febrile Illness for Leptospirosis Using Clinical Criteria and Serology. Natl Med J India. 2005 Sep-Oct;18(5):244-6. PubMed PMID: 16433137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology. AU - Rao,P, AU - Sethi,S, AU - Sud,A, AU - Banga,S S, AU - Sharma,M, PY - 2006/1/26/pubmed PY - 2006/3/15/medline PY - 2006/1/26/entrez SP - 244 EP - 6 JF - The National medical journal of India JO - Natl Med J India VL - 18 IS - 5 N2 - BACKGROUND: Leptospirosis is one of the common zoonoses but, in most instances, the infection goes unnoticed. Rapid diagnostic modalities are needed to diagnose the disease in the early stages. We assessed the usefulness of clinical criteria and compared these with enzyme-linked immunosorbentassay (ELISA) for the early detection of leptospirosis. METHODS: One hundred patients with a febrile illness for > 7 days were screened by Faine criteria and their sera were subjected to both IgM and IgG ELISA using a commercially available kit (Institut Virion Serion GmbH, Warburg, Germany). RESULTS: Twenty-six patients satisfied the clinical criteria for leptospirosis and 8 of them tested positive for IgM antibodies while 1 patient who was clinically negative tested positive by serology. Thus, Faine criteria had a sensitivity of 88.9%, specificity of 80.2%, positive predictive value of 30.8% and a negative predictive value of 98.6%. Paired serum samples were obtained from 70 patients but the IgG levels of only 2 showed a 4-fold rise. CONCLUSION: Faine criteria has moderate sensitivity and specificity but a high negative predictive value in comparison with IgM ELISA. The high negative predictive value may help to screen patients with acute febrile illness for leptospirosis during the early phase of the disease. SN - 0970-258X UR - https://www.unboundmedicine.com/medline/citation/16433137/Screening_of_patients_with_acute_febrile_illness_for_leptospirosis_using_clinical_criteria_and_serology_ L2 - http://www.diseaseinfosearch.org/result/4178 DB - PRIME DP - Unbound Medicine ER -