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Protection of skin biological targets by different types of sunscreens.
Photodermatol Photoimmunol Photomed. 2006 Feb; 22(1):22-32.PP

Abstract

In vitro and in vivo studies provide a body of evidence that adequate protection of the skin against ultraviolet (UV)-induced damage requires photostable broad-spectrum sunscreens with a proper level of UVA protection. UVA alone and UV solar simulated radiation (SSR) induce DNA lesions in keratinocytes and melanocytes as reflected by the comet assay and p53 accumulation. UVA and SSR impair the immune system as shown by significant alteration of Langerhans cells and inhibition of contact hypersensitivity response to chemical allergens and delayed-type hypersensitivity response to recall antigens. Any of these detrimental effects is more efficiently prevented by sunscreens with a higher level of protection in the UVA range. The involvement of UVA (fibroblast alteration, increased metalloproteinase expression) and the pivotal need for well-balanced UVA/UVB sunscreens were further demonstrated using reconstructed three-dimensional skin models.

Authors+Show Affiliations

L'Oréal Recherche, Clichy Cedex, France. afourtanier@rd.loreal.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16436178

Citation

Fourtanier, A, et al. "Protection of Skin Biological Targets By Different Types of Sunscreens." Photodermatology, Photoimmunology & Photomedicine, vol. 22, no. 1, 2006, pp. 22-32.
Fourtanier A, Bernerd F, Bouillon C, et al. Protection of skin biological targets by different types of sunscreens. Photodermatol Photoimmunol Photomed. 2006;22(1):22-32.
Fourtanier, A., Bernerd, F., Bouillon, C., Marrot, L., Moyal, D., & Seité, S. (2006). Protection of skin biological targets by different types of sunscreens. Photodermatology, Photoimmunology & Photomedicine, 22(1), 22-32.
Fourtanier A, et al. Protection of Skin Biological Targets By Different Types of Sunscreens. Photodermatol Photoimmunol Photomed. 2006;22(1):22-32. PubMed PMID: 16436178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection of skin biological targets by different types of sunscreens. AU - Fourtanier,A, AU - Bernerd,F, AU - Bouillon,C, AU - Marrot,L, AU - Moyal,D, AU - Seité,S, PY - 2006/1/27/pubmed PY - 2006/7/14/medline PY - 2006/1/27/entrez SP - 22 EP - 32 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 22 IS - 1 N2 - In vitro and in vivo studies provide a body of evidence that adequate protection of the skin against ultraviolet (UV)-induced damage requires photostable broad-spectrum sunscreens with a proper level of UVA protection. UVA alone and UV solar simulated radiation (SSR) induce DNA lesions in keratinocytes and melanocytes as reflected by the comet assay and p53 accumulation. UVA and SSR impair the immune system as shown by significant alteration of Langerhans cells and inhibition of contact hypersensitivity response to chemical allergens and delayed-type hypersensitivity response to recall antigens. Any of these detrimental effects is more efficiently prevented by sunscreens with a higher level of protection in the UVA range. The involvement of UVA (fibroblast alteration, increased metalloproteinase expression) and the pivotal need for well-balanced UVA/UVB sunscreens were further demonstrated using reconstructed three-dimensional skin models. SN - 0905-4383 UR - https://www.unboundmedicine.com/medline/citation/16436178/Protection_of_skin_biological_targets_by_different_types_of_sunscreens_ L2 - https://doi.org/10.1111/j.1600-0781.2006.00188.x DB - PRIME DP - Unbound Medicine ER -