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Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary.
World J Gastroenterol 2005; 11(48):7646-50WJ

Abstract

AIM

To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers.

METHODS

The changes in serum levels of retinoids (vitamin A, alpha- and beta-carotene, alpha- and beta-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.

RESULTS

The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of alpha- and beta-carotene, alpha- and beta-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.

CONCLUSION

Retinoids (as environmental factors) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer.

Authors+Show Affiliations

First Department of Medicine, Medical and Health Centre, University of Pecs, Hungary. gyula.mozsik@aok.pte.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16437692

Citation

Mózsik, Gyula, et al. "Involvement of Serum Retinoids and Leiden Mutation in Patients With Esophageal, Gastric, Liver, Pancreatic, and Colorectal Cancers in Hungary." World Journal of Gastroenterology, vol. 11, no. 48, 2005, pp. 7646-50.
Mózsik G, Rumi G, Dömötör A, et al. Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary. World J Gastroenterol. 2005;11(48):7646-50.
Mózsik, G., Rumi, G., Dömötör, A., Figler, M., Gasztonyi, B., Papp, E., ... Melegh, B. (2005). Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary. World Journal of Gastroenterology, 11(48), pp. 7646-50.
Mózsik G, et al. Involvement of Serum Retinoids and Leiden Mutation in Patients With Esophageal, Gastric, Liver, Pancreatic, and Colorectal Cancers in Hungary. World J Gastroenterol. 2005 Dec 28;11(48):7646-50. PubMed PMID: 16437692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary. AU - Mózsik,Gyula, AU - Rumi,György, AU - Dömötör,András, AU - Figler,Mária, AU - Gasztonyi,Beáta, AU - Papp,Elod, AU - Pár,Alajos, AU - Pár,Gabriella, AU - Belágyi,József, AU - Matus,Zoltán, AU - Melegh,Béla, PY - 2006/1/27/pubmed PY - 2006/4/14/medline PY - 2006/1/27/entrez SP - 7646 EP - 50 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 11 IS - 48 N2 - AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers. METHODS: The changes in serum levels of retinoids (vitamin A, alpha- and beta-carotene, alpha- and beta-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used. RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of alpha- and beta-carotene, alpha- and beta-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer. CONCLUSION: Retinoids (as environmental factors) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/16437692/Involvement_of_serum_retinoids_and_Leiden_mutation_in_patients_with_esophageal_gastric_liver_pancreatic_and_colorectal_cancers_in_Hungary_ L2 - http://www.wjgnet.com/1007-9327/full/v11/i48/7646.htm DB - PRIME DP - Unbound Medicine ER -