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Cancer-associated malnutrition.
Eur J Oncol Nurs. 2005; 9 Suppl 2:S39-50.EJ

Abstract

Malnutrition is a common problem among patients with cancer, affecting up to 85% of patients with certain cancers (e.g. pancreas). In severe cases, malnutrition can progress to cachexia, a specific form of malnutrition characterised by loss of lean body mass, muscle wasting, and impaired immune, physical and mental function. Cancer cachexia is also associated with poor response to therapy, increased susceptibility to treatment-related adverse events, as well as poor outcome and quality of life. Cancer cachexia is a complex, multifactorial syndrome, which is thought to result from the actions of both host- and tumour-derived factors, including cytokines involved in a systemic inflammatory response to the tumour. Early intervention with nutritional supplementation has been shown to halt malnutrition, and may improve outcome in some patients. However, increasing nutritional intake is insufficient to prevent the development of cachexia, reflecting the complex pathogenesis of this condition. Nutritional supplements containing anti-inflammatory agents, for example the polyunsaturated fatty acid (PUFA) eicosapentanoic acid (EPA), have been shown to be more beneficial to malnourished patients than nutritional supplementation alone. EPA has been shown to interfere with multiple mechanisms implicated in the pathogenesis of cancer cachexia, and in clinical studies, has been associated with reversal of cachexia and improved survival.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain. argiles@porthos.bio.ub.es

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16437757

Citation

Argilés, J M.. "Cancer-associated Malnutrition." European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, vol. 9 Suppl 2, 2005, pp. S39-50.
Argilés JM. Cancer-associated malnutrition. Eur J Oncol Nurs. 2005;9 Suppl 2:S39-50.
Argilés, J. M. (2005). Cancer-associated malnutrition. European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, 9 Suppl 2, S39-50.
Argilés JM. Cancer-associated Malnutrition. Eur J Oncol Nurs. 2005;9 Suppl 2:S39-50. PubMed PMID: 16437757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer-associated malnutrition. A1 - Argilés,J M, PY - 2006/1/27/pubmed PY - 2006/2/10/medline PY - 2006/1/27/entrez SP - S39 EP - 50 JF - European journal of oncology nursing : the official journal of European Oncology Nursing Society JO - Eur J Oncol Nurs VL - 9 Suppl 2 N2 - Malnutrition is a common problem among patients with cancer, affecting up to 85% of patients with certain cancers (e.g. pancreas). In severe cases, malnutrition can progress to cachexia, a specific form of malnutrition characterised by loss of lean body mass, muscle wasting, and impaired immune, physical and mental function. Cancer cachexia is also associated with poor response to therapy, increased susceptibility to treatment-related adverse events, as well as poor outcome and quality of life. Cancer cachexia is a complex, multifactorial syndrome, which is thought to result from the actions of both host- and tumour-derived factors, including cytokines involved in a systemic inflammatory response to the tumour. Early intervention with nutritional supplementation has been shown to halt malnutrition, and may improve outcome in some patients. However, increasing nutritional intake is insufficient to prevent the development of cachexia, reflecting the complex pathogenesis of this condition. Nutritional supplements containing anti-inflammatory agents, for example the polyunsaturated fatty acid (PUFA) eicosapentanoic acid (EPA), have been shown to be more beneficial to malnourished patients than nutritional supplementation alone. EPA has been shown to interfere with multiple mechanisms implicated in the pathogenesis of cancer cachexia, and in clinical studies, has been associated with reversal of cachexia and improved survival. SN - 1462-3889 UR - https://www.unboundmedicine.com/medline/citation/16437757/Cancer_associated_malnutrition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1462-3889(05)00108-0 DB - PRIME DP - Unbound Medicine ER -