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The effects of sufentanil or morphine added to hyperbaric bupivacaine in spinal anaesthesia for caesarean section.
Eur J Anaesthesiol. 2006 Apr; 23(4):285-91.EJ

Abstract

BACKGROUND AND OBJECTIVE

The quality of spinal anaesthesia, often used for Caesarean section, can be improved by adding an opioid to the local anaesthetic. This study compared the quality of anaesthesia, postoperative analgesia, and adverse effects on mother and neonate when either sufentanil 5 microg or morphine 0.2 mg was added to intrathecal hyperbaric bupivacaine for Caesarean section.

METHODS

This prospective, randomized and double-blind study encompassed 54 females undergoing Caesarean section. Spinal anaesthesia was obtained with 2 mL of 0.5% bupivacaine supplemented with either 0.2 mg morphine or 5 microg sufentanil. Characteristics of spinal block, intraoperative analgesia, maternal and neonatal side-effects and the time to first request for analgesics were assessed.

RESULTS

There were no differences in the onset time of sensory block, time to sensory block to T10, time to highest sensory block, highest sensory block level, time to regression of sensory block to T10 level and time to resolution of motor blockade. Perioperative haemodynamic parameters, neonatal Apgar scores, neurological and adaptive capacity scores, umbilical blood gas values, sedation scores, nausea-vomiting and pruritus incidences were similar in both groups. The time to the first request for an analgesic was significantly longer (19.5 +/- 4.7 h vs. 6.3 +/- 5.2 h) in patients given morphine (P < 0.05).

CONCLUSIONS

The addition of 5 microg sufentanil or 0.2 mg morphine to hyperbaric bupivacaine for Caesarean section both provided safe and effective anaesthesia. Morphine increased the duration of postoperative analgesia compared with sufentanil without increasing maternal or neonatal side-effects.

Authors+Show Affiliations

Ege University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Izmir, Turkey. skaraman@med.ege.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16438758

Citation

Karaman, S, et al. "The Effects of Sufentanil or Morphine Added to Hyperbaric Bupivacaine in Spinal Anaesthesia for Caesarean Section." European Journal of Anaesthesiology, vol. 23, no. 4, 2006, pp. 285-91.
Karaman S, Kocabas S, Uyar M, et al. The effects of sufentanil or morphine added to hyperbaric bupivacaine in spinal anaesthesia for caesarean section. Eur J Anaesthesiol. 2006;23(4):285-91.
Karaman, S., Kocabas, S., Uyar, M., Hayzaran, S., & Firat, V. (2006). The effects of sufentanil or morphine added to hyperbaric bupivacaine in spinal anaesthesia for caesarean section. European Journal of Anaesthesiology, 23(4), 285-91.
Karaman S, et al. The Effects of Sufentanil or Morphine Added to Hyperbaric Bupivacaine in Spinal Anaesthesia for Caesarean Section. Eur J Anaesthesiol. 2006;23(4):285-91. PubMed PMID: 16438758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of sufentanil or morphine added to hyperbaric bupivacaine in spinal anaesthesia for caesarean section. AU - Karaman,S, AU - Kocabas,S, AU - Uyar,M, AU - Hayzaran,S, AU - Firat,V, Y1 - 2006/01/27/ PY - 2005/11/20/accepted PY - 2006/1/28/pubmed PY - 2006/7/29/medline PY - 2006/1/28/entrez SP - 285 EP - 91 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 23 IS - 4 N2 - BACKGROUND AND OBJECTIVE: The quality of spinal anaesthesia, often used for Caesarean section, can be improved by adding an opioid to the local anaesthetic. This study compared the quality of anaesthesia, postoperative analgesia, and adverse effects on mother and neonate when either sufentanil 5 microg or morphine 0.2 mg was added to intrathecal hyperbaric bupivacaine for Caesarean section. METHODS: This prospective, randomized and double-blind study encompassed 54 females undergoing Caesarean section. Spinal anaesthesia was obtained with 2 mL of 0.5% bupivacaine supplemented with either 0.2 mg morphine or 5 microg sufentanil. Characteristics of spinal block, intraoperative analgesia, maternal and neonatal side-effects and the time to first request for analgesics were assessed. RESULTS: There were no differences in the onset time of sensory block, time to sensory block to T10, time to highest sensory block, highest sensory block level, time to regression of sensory block to T10 level and time to resolution of motor blockade. Perioperative haemodynamic parameters, neonatal Apgar scores, neurological and adaptive capacity scores, umbilical blood gas values, sedation scores, nausea-vomiting and pruritus incidences were similar in both groups. The time to the first request for an analgesic was significantly longer (19.5 +/- 4.7 h vs. 6.3 +/- 5.2 h) in patients given morphine (P < 0.05). CONCLUSIONS: The addition of 5 microg sufentanil or 0.2 mg morphine to hyperbaric bupivacaine for Caesarean section both provided safe and effective anaesthesia. Morphine increased the duration of postoperative analgesia compared with sufentanil without increasing maternal or neonatal side-effects. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/16438758/The_effects_of_sufentanil_or_morphine_added_to_hyperbaric_bupivacaine_in_spinal_anaesthesia_for_caesarean_section_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=16438758.ui DB - PRIME DP - Unbound Medicine ER -