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A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan.
Eur J Anaesthesiol. 2006 Apr; 23(4):341-5.EJ

Abstract

BACKGROUND AND OBJECTIVE

We compared the dose requirement and side effect profile of total intravenous anaesthesia using Diprivan to generic propofol at a specific anaesthetic target level utilizing the bispectral index monitor to determine efficacy differences between the two products.

METHODS

Sixty women undergoing abdominal hysterectomy were induced with propofol 2 mg kg-1 and maintained with infusion (20-200 microg kg-1 min-1) adjusted to maintain a bispectral index of 50-65. Plasma propofol concentration was measured at 1 and 2 h post induction in 25 patients.

RESULTS

Mean (SD) drug doses adjusted for weight and time were similar in the Diprivan and generic propofol groups: 90 (30) microg kg-1 min-1 vs. 90 (20) microg kg-1 min-1 respectively. Mean (SD) plasma propofol levels at 1 and 2 h were also similar (3.0 (1.0) microg mL-1 vs. 3.6 (1.4) microg mL-1, P = 0.2 and 3.0 (1.9) microg mL-1 vs. 3.4 (1.6) microg mL-1, P = 0.58).

CONCLUSIONS

Diprivan and generic propofol have similar efficacy at a specified, bispectral index-defined, depth of anaesthesia.

Authors+Show Affiliations

Duke University Medical Center, Department of Anesthesiology, Division of Women's Anaesthesia Research Group, Durham, NC 27710, USA. olufo001@mc.duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16438763

Citation

Olufolabi, A J., et al. "A Randomized, Prospective Double-blind Comparison of the Efficacy of Generic Propofol (sulphite Additive) With Diprivan." European Journal of Anaesthesiology, vol. 23, no. 4, 2006, pp. 341-5.
Olufolabi AJ, Gan TJ, Lacassie HJ, et al. A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. Eur J Anaesthesiol. 2006;23(4):341-5.
Olufolabi, A. J., Gan, T. J., Lacassie, H. J., White, W. D., & Habib, A. S. (2006). A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. European Journal of Anaesthesiology, 23(4), 341-5.
Olufolabi AJ, et al. A Randomized, Prospective Double-blind Comparison of the Efficacy of Generic Propofol (sulphite Additive) With Diprivan. Eur J Anaesthesiol. 2006;23(4):341-5. PubMed PMID: 16438763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. AU - Olufolabi,A J, AU - Gan,T J, AU - Lacassie,H J, AU - White,W D, AU - Habib,A S, Y1 - 2006/01/27/ PY - 2005/12/04/accepted PY - 2006/1/28/pubmed PY - 2006/7/29/medline PY - 2006/1/28/entrez SP - 341 EP - 5 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 23 IS - 4 N2 - BACKGROUND AND OBJECTIVE: We compared the dose requirement and side effect profile of total intravenous anaesthesia using Diprivan to generic propofol at a specific anaesthetic target level utilizing the bispectral index monitor to determine efficacy differences between the two products. METHODS: Sixty women undergoing abdominal hysterectomy were induced with propofol 2 mg kg-1 and maintained with infusion (20-200 microg kg-1 min-1) adjusted to maintain a bispectral index of 50-65. Plasma propofol concentration was measured at 1 and 2 h post induction in 25 patients. RESULTS: Mean (SD) drug doses adjusted for weight and time were similar in the Diprivan and generic propofol groups: 90 (30) microg kg-1 min-1 vs. 90 (20) microg kg-1 min-1 respectively. Mean (SD) plasma propofol levels at 1 and 2 h were also similar (3.0 (1.0) microg mL-1 vs. 3.6 (1.4) microg mL-1, P = 0.2 and 3.0 (1.9) microg mL-1 vs. 3.4 (1.6) microg mL-1, P = 0.58). CONCLUSIONS: Diprivan and generic propofol have similar efficacy at a specified, bispectral index-defined, depth of anaesthesia. SN - 0265-0215 UR - https://www.unboundmedicine.com/medline/citation/16438763/A_randomized_prospective_double_blind_comparison_of_the_efficacy_of_generic_propofol__sulphite_additive__with_diprivan_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16438763.ui DB - PRIME DP - Unbound Medicine ER -