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Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula.
Pediatr Res. 2006 Feb; 59(2):271-5.PR

Abstract

Docosahexaenoic acid (DHA) is an integral component of neural cell membranes and is critical to the development and function of the CNS. A premature delivery interrupts normal placental supply of DHA such that the infant is dependent on the nature of the nutritional support offered. The most abundant omega-3 fatty acid in pre-term formulas is alpha linolenic acid (ALNA), the precursor of DHA. This project studied the absorption, beta-oxidation and conversion of ALNA to DHA by pre-term infants ranging from 30-37 wk of corrected gestation. [U-(13)C] ALNA was administered emulsified with a pre-term formula to 20 well pre-term infants on full enteral feeds. Enrichment of (13)C in stool and as (13)CO(2) in breath was used to estimate absorption across the gut and partitioning toward beta-oxidation respectively. Excretion of the administered dose of (13)C in stool ranged from 2.0 to 26.2%; excretion decreased with increasing birth gestation. Appearance as (13)CO(2) on breath ranged from 7.6 to 19.0%. All infants synthesised eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and DHA with the least mature having the highest cumulative plasma DHA. These results show considerable variation suggesting that the worst absorption of ALNA and the greatest production of DHA occur in infants born at the earliest gestation.

Authors+Show Affiliations

Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16439591

Citation

Mayes, Clifford, et al. "Variation in [U-13C] Alpha Linolenic Acid Absorption, Beta-oxidation and Conversion to Docosahexaenoic Acid in the Pre-term Infant Fed a DHA-enriched Formula." Pediatric Research, vol. 59, no. 2, 2006, pp. 271-5.
Mayes C, Burdge GC, Bingham A, et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. Pediatr Res. 2006;59(2):271-5.
Mayes, C., Burdge, G. C., Bingham, A., Murphy, J. L., Tubman, R., & Wootton, S. A. (2006). Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. Pediatric Research, 59(2), 271-5.
Mayes C, et al. Variation in [U-13C] Alpha Linolenic Acid Absorption, Beta-oxidation and Conversion to Docosahexaenoic Acid in the Pre-term Infant Fed a DHA-enriched Formula. Pediatr Res. 2006;59(2):271-5. PubMed PMID: 16439591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. AU - Mayes,Clifford, AU - Burdge,Graham C, AU - Bingham,Anne, AU - Murphy,Jane L, AU - Tubman,Richard, AU - Wootton,Stephen A, PY - 2006/1/28/pubmed PY - 2006/5/19/medline PY - 2006/1/28/entrez SP - 271 EP - 5 JF - Pediatric research JO - Pediatr Res VL - 59 IS - 2 N2 - Docosahexaenoic acid (DHA) is an integral component of neural cell membranes and is critical to the development and function of the CNS. A premature delivery interrupts normal placental supply of DHA such that the infant is dependent on the nature of the nutritional support offered. The most abundant omega-3 fatty acid in pre-term formulas is alpha linolenic acid (ALNA), the precursor of DHA. This project studied the absorption, beta-oxidation and conversion of ALNA to DHA by pre-term infants ranging from 30-37 wk of corrected gestation. [U-(13)C] ALNA was administered emulsified with a pre-term formula to 20 well pre-term infants on full enteral feeds. Enrichment of (13)C in stool and as (13)CO(2) in breath was used to estimate absorption across the gut and partitioning toward beta-oxidation respectively. Excretion of the administered dose of (13)C in stool ranged from 2.0 to 26.2%; excretion decreased with increasing birth gestation. Appearance as (13)CO(2) on breath ranged from 7.6 to 19.0%. All infants synthesised eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and DHA with the least mature having the highest cumulative plasma DHA. These results show considerable variation suggesting that the worst absorption of ALNA and the greatest production of DHA occur in infants born at the earliest gestation. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/16439591/Variation_in_[U_13C]_alpha_linolenic_acid_absorption_beta_oxidation_and_conversion_to_docosahexaenoic_acid_in_the_pre_term_infant_fed_a_DHA_enriched_formula_ L2 - https://doi.org/10.1203/01.pdr.0000196372.29648.7a DB - PRIME DP - Unbound Medicine ER -