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Prediction of cardiovascular morbidity and mortality: comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness.
Stroke 2006; 37(3):800-5S

Abstract

BACKGROUND AND PURPOSE

The intima-media thickness (IMT) of the common carotid artery (CCA) is well correlated with the degree of arteriosclerosis and is a predictor of cardiovascular morbidity and mortality. The (hemodynamic) resistive index (RI) of the internal carotid artery (ICA) correlates with the degree of arteriosclerosis just as well as IMT. The aim of the study was to compare the predictive values of RI and IMT with regard to cardiovascular morbidity and mortality.

METHODS

A total of 146 patients with cardiovascular risk factors or established arteriosclerosis were included. Duplex sonography of the CCA and ICA was performed, and the IMT and RI were measured in both vessels. During follow-up for a median of 36 months, the occurrence of cardiovascular events (myocardial infarction, stroke, or cardiovascular death) was assessed.

RESULTS

Thirty-nine cardiovascular events occurred in 28 patients (19.2%). The relative risk for a cardiovascular event per increase of the IMT by 1 SD (0.16 mm) was 1.53 (95% CI, 1.07 to 2.18) and 1.91 (95% CI, 1.34 to 2.73) for RI ICA (0.08). The event rate in patients with IMT <0.79 mm (mean) and RI ICA <0.66 (mean) was 11.8% and 12.7% compared with 25.6% (P=0.03) and 25.0% (P=0.06) in patients with IMT > or =0.79 mm and RI ICA > or =0.66, respectively. Log rank analysis showed a continuous increase in the risk of cardiovascular event with increasing range of the IMT (P=0.029) and RI ICA (P<0.001).

CONCLUSIONS

The RI ICA is a predictor of cardiovascular mortality and morbidity, at least comparable to the well-established IMT.

Authors+Show Affiliations

Department of Internal Medicine, Cantonal Hospital, Frauenfeld, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16439703

Citation

Staub, Daniel, et al. "Prediction of Cardiovascular Morbidity and Mortality: Comparison of the Internal Carotid Artery Resistive Index With the Common Carotid Artery Intima-media Thickness." Stroke, vol. 37, no. 3, 2006, pp. 800-5.
Staub D, Meyerhans A, Bundi B, et al. Prediction of cardiovascular morbidity and mortality: comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness. Stroke. 2006;37(3):800-5.
Staub, D., Meyerhans, A., Bundi, B., Schmid, H. P., & Frauchiger, B. (2006). Prediction of cardiovascular morbidity and mortality: comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness. Stroke, 37(3), pp. 800-5.
Staub D, et al. Prediction of Cardiovascular Morbidity and Mortality: Comparison of the Internal Carotid Artery Resistive Index With the Common Carotid Artery Intima-media Thickness. Stroke. 2006;37(3):800-5. PubMed PMID: 16439703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prediction of cardiovascular morbidity and mortality: comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness. AU - Staub,Daniel, AU - Meyerhans,Alessandro, AU - Bundi,Beat, AU - Schmid,Hans Peter, AU - Frauchiger,Beat, Y1 - 2006/01/26/ PY - 2006/1/28/pubmed PY - 2006/3/24/medline PY - 2006/1/28/entrez SP - 800 EP - 5 JF - Stroke JO - Stroke VL - 37 IS - 3 N2 - BACKGROUND AND PURPOSE: The intima-media thickness (IMT) of the common carotid artery (CCA) is well correlated with the degree of arteriosclerosis and is a predictor of cardiovascular morbidity and mortality. The (hemodynamic) resistive index (RI) of the internal carotid artery (ICA) correlates with the degree of arteriosclerosis just as well as IMT. The aim of the study was to compare the predictive values of RI and IMT with regard to cardiovascular morbidity and mortality. METHODS: A total of 146 patients with cardiovascular risk factors or established arteriosclerosis were included. Duplex sonography of the CCA and ICA was performed, and the IMT and RI were measured in both vessels. During follow-up for a median of 36 months, the occurrence of cardiovascular events (myocardial infarction, stroke, or cardiovascular death) was assessed. RESULTS: Thirty-nine cardiovascular events occurred in 28 patients (19.2%). The relative risk for a cardiovascular event per increase of the IMT by 1 SD (0.16 mm) was 1.53 (95% CI, 1.07 to 2.18) and 1.91 (95% CI, 1.34 to 2.73) for RI ICA (0.08). The event rate in patients with IMT <0.79 mm (mean) and RI ICA <0.66 (mean) was 11.8% and 12.7% compared with 25.6% (P=0.03) and 25.0% (P=0.06) in patients with IMT > or =0.79 mm and RI ICA > or =0.66, respectively. Log rank analysis showed a continuous increase in the risk of cardiovascular event with increasing range of the IMT (P=0.029) and RI ICA (P<0.001). CONCLUSIONS: The RI ICA is a predictor of cardiovascular mortality and morbidity, at least comparable to the well-established IMT. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/16439703/Prediction_of_cardiovascular_morbidity_and_mortality:_comparison_of_the_internal_carotid_artery_resistive_index_with_the_common_carotid_artery_intima_media_thickness_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000202589.47401.c6?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -