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Disease progression in patients with virological suppression in response to HAART is associated with the degree of immunological response.
AIDS. 2006 Feb 14; 20(3):371-7.AIDS

Abstract

OBJECTIVE

To determine if immunological response is associated with disease progression in patients with virological suppression after initiating HAART.

DESIGN

A cohort study of 1084 treatment-naive participants in the British Columbia HIV/AIDS Drug Treatment Program who had achieved viral loads < 500 copies/ml at 3-9 months after initiating triple-drug therapy.

METHODS

Cox proportional hazards was used to model the association with disease progression of baseline variables, change in CD4 cell counts and CD4 cell count strata at 6 months. Logistic regression analysis was used to examine associations with two definitions of poor immunological response.

RESULTS

Patients were followed for a median of 51.4 months. In univariate analyses, increases in CD4 cell counts of < 25 cells/microl and absolute CD4 cell counts of < 200 cells/microl were associated with an increased risk of death or new AIDS events. Two mulitivariate models, one including baseline CD4 cell count and change in CD4 cell count from baseline and the other including only absolute CD4 cell counts at 6 months, were found to predict disease progression in this setting. Increases in CD4 cell count of < 25 cells/microl were associated with increasing age and inversely associated with low baseline CD4 cell counts, high baseline viral loads and good adherence to therapy. CD4 cell counts of < 200 cells/microl at 6 months were associated with low baseline CD4 cell counts and having AIDS at baseline.

CONCLUSION

Patients with virological suppression are still at risk for HIV disease progression if adequate immunological responses are not achieved.

Authors+Show Affiliations

BC Centre for Excellence in HIV/AIDS, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. dmoore@cfenet.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16439870

Citation

Moore, David M., et al. "Disease Progression in Patients With Virological Suppression in Response to HAART Is Associated With the Degree of Immunological Response." AIDS (London, England), vol. 20, no. 3, 2006, pp. 371-7.
Moore DM, Hogg RS, Chan K, et al. Disease progression in patients with virological suppression in response to HAART is associated with the degree of immunological response. AIDS. 2006;20(3):371-7.
Moore, D. M., Hogg, R. S., Chan, K., Tyndall, M., Yip, B., & Montaner, J. S. (2006). Disease progression in patients with virological suppression in response to HAART is associated with the degree of immunological response. AIDS (London, England), 20(3), 371-7.
Moore DM, et al. Disease Progression in Patients With Virological Suppression in Response to HAART Is Associated With the Degree of Immunological Response. AIDS. 2006 Feb 14;20(3):371-7. PubMed PMID: 16439870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disease progression in patients with virological suppression in response to HAART is associated with the degree of immunological response. AU - Moore,David M, AU - Hogg,Robert S, AU - Chan,Keith, AU - Tyndall,Mark, AU - Yip,Benita, AU - Montaner,Julio S G, PY - 2006/1/28/pubmed PY - 2006/10/21/medline PY - 2006/1/28/entrez SP - 371 EP - 7 JF - AIDS (London, England) JO - AIDS VL - 20 IS - 3 N2 - OBJECTIVE: To determine if immunological response is associated with disease progression in patients with virological suppression after initiating HAART. DESIGN: A cohort study of 1084 treatment-naive participants in the British Columbia HIV/AIDS Drug Treatment Program who had achieved viral loads < 500 copies/ml at 3-9 months after initiating triple-drug therapy. METHODS: Cox proportional hazards was used to model the association with disease progression of baseline variables, change in CD4 cell counts and CD4 cell count strata at 6 months. Logistic regression analysis was used to examine associations with two definitions of poor immunological response. RESULTS: Patients were followed for a median of 51.4 months. In univariate analyses, increases in CD4 cell counts of < 25 cells/microl and absolute CD4 cell counts of < 200 cells/microl were associated with an increased risk of death or new AIDS events. Two mulitivariate models, one including baseline CD4 cell count and change in CD4 cell count from baseline and the other including only absolute CD4 cell counts at 6 months, were found to predict disease progression in this setting. Increases in CD4 cell count of < 25 cells/microl were associated with increasing age and inversely associated with low baseline CD4 cell counts, high baseline viral loads and good adherence to therapy. CD4 cell counts of < 200 cells/microl at 6 months were associated with low baseline CD4 cell counts and having AIDS at baseline. CONCLUSION: Patients with virological suppression are still at risk for HIV disease progression if adequate immunological responses are not achieved. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/16439870/Disease_progression_in_patients_with_virological_suppression_in_response_to_HAART_is_associated_with_the_degree_of_immunological_response_ L2 - http://Insights.ovid.com/pubmed?pmid=16439870 DB - PRIME DP - Unbound Medicine ER -