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Epstein-Barr virus-associated lymphomas.
Expert Rev Anti Infect Ther 2006; 4(1):77-89ER

Abstract

Following Epstein and colleagues' ground-breaking discovery of Epstein-Barr virus by electron microscopy of Burkitt's lymphoma cell lines, there came the observation that Epstein-Barr virus induces immortalization of B cells in vitro. Thus, initial hopes were of a virus confined to equatorial Africa with a causal link to a particular subtype of childhood lymphoma. Over the past 40 years there has been great progress towards understanding the biology and epidemiology of Epstein-Barr virus, which conclusively show that these early ideas were overly simplistic. It is now known that Epstein-Barr virus has a seroprevalence of approximately 95% worldwide, and persists for life within host B lymphocytes. Infection in New World primates leads to lymphoma and inoculation of peripheral blood mononuclear cells from Epstein-Barr virus-seropositive subjects into severe combined immunodeficiency mice results in B-cell lymphoproliferative disorders. Epstein-Barr virus is now known to be implicated in a range of lymphoid and other malignancies, and this association will be the subject of this review.

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    Authors+Show Affiliations

    Gandhi MK
    Tumor Immunology Lab, Level I, CRC, QIMR, Brisbane, 4006, Queensland, Australia. maher.gandhi@qimr.edu.au

    MeSH

    AdolescentAdultBurkitt LymphomaChildChild, PreschoolEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHodgkin DiseaseHumansLymphomaLymphoproliferative DisordersMiddle AgedVirus Latency

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16441211

    Citation

    Gandhi, Maher K.. "Epstein-Barr Virus-associated Lymphomas." Expert Review of Anti-infective Therapy, vol. 4, no. 1, 2006, pp. 77-89.
    Gandhi MK. Epstein-Barr virus-associated lymphomas. Expert Rev Anti Infect Ther. 2006;4(1):77-89.
    Gandhi, M. K. (2006). Epstein-Barr virus-associated lymphomas. Expert Review of Anti-infective Therapy, 4(1), pp. 77-89.
    Gandhi MK. Epstein-Barr Virus-associated Lymphomas. Expert Rev Anti Infect Ther. 2006;4(1):77-89. PubMed PMID: 16441211.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epstein-Barr virus-associated lymphomas. A1 - Gandhi,Maher K, PY - 2006/1/31/pubmed PY - 2006/3/24/medline PY - 2006/1/31/entrez SP - 77 EP - 89 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 4 IS - 1 N2 - Following Epstein and colleagues' ground-breaking discovery of Epstein-Barr virus by electron microscopy of Burkitt's lymphoma cell lines, there came the observation that Epstein-Barr virus induces immortalization of B cells in vitro. Thus, initial hopes were of a virus confined to equatorial Africa with a causal link to a particular subtype of childhood lymphoma. Over the past 40 years there has been great progress towards understanding the biology and epidemiology of Epstein-Barr virus, which conclusively show that these early ideas were overly simplistic. It is now known that Epstein-Barr virus has a seroprevalence of approximately 95% worldwide, and persists for life within host B lymphocytes. Infection in New World primates leads to lymphoma and inoculation of peripheral blood mononuclear cells from Epstein-Barr virus-seropositive subjects into severe combined immunodeficiency mice results in B-cell lymphoproliferative disorders. Epstein-Barr virus is now known to be implicated in a range of lymphoid and other malignancies, and this association will be the subject of this review. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/16441211/Epstein_Barr_virus_associated_lymphomas_ L2 - http://www.tandfonline.com/doi/full/10.1586/14787210.4.1.77 DB - PRIME DP - Unbound Medicine ER -