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Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy.

Abstract

OBJECTIVE

To analyze the relationship between surgically treated benign prostatic hyperplasia (BPH) and intake of selected micronutrients.

METHODS

A multicentric case-control study was conducted in Italy between 1991 and 2002. Cases were 1369 men with histologically confirmed, surgically treated BPH and controls were 1451 men younger than 75 yr, frequency matched by quinquennium of age and study center, admitted to the hospital for acute nonneoplastic diseases. Information was collected by trained interviewers using a structured validated food-frequency questionnaire. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multiple logistic regression models.

RESULTS

The risk of BPH significantly decreased with increasing intake of carotene (OR=0.80 for an increment equal to the difference between the 80th and 20th percentile of intake), alpha-carotene (OR=0.83), beta-carotene (OR=0.82), and cis beta-carotene (OR=0.82) and tended to decrease with the intake of vitamin C (OR=0.89) and iron (OR=0.79). The OR tended to increase with the intake of sodium (OR=1.30) and zinc (OR=1.10). No systematic heterogeneity was observed across strata of age, education, and body mass index. No meaningful associations emerged for other antioxidants, such as folic acid, lycopene, lutein/zeaxanthin, vitamin E, vitamin D, nor for retinol.

CONCLUSIONS

Our results suggest a protective effect of carotene on the risk of BPH. The risk tended to decrease also with the intake of vitamin C and iron and tended to increase with the intake of sodium and zinc. Results also indicate that other antioxidants, including folic acid, lycopene, lutein/zeaxanthin, and vitamins D and E, and retinol were not related to the risk for this disease.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. tavani@marionegri.it

    , , , , , , , ,

    Source

    European urology 50:3 2006 Sep pg 549-54

    MeSH

    Adult
    Aged
    Carotenoids
    Case-Control Studies
    Eating
    Educational Status
    Feeding Behavior
    Humans
    Italy
    Male
    Micronutrients
    Middle Aged
    Prostatic Hyperplasia
    Risk Factors
    Social Class

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16442205

    Citation

    Tavani, Alessandra, et al. "Intake of Selected Micronutrients and the Risk of Surgically Treated Benign Prostatic Hyperplasia: a Case-control Study From Italy." European Urology, vol. 50, no. 3, 2006, pp. 549-54.
    Tavani A, Longoni E, Bosetti C, et al. Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy. Eur Urol. 2006;50(3):549-54.
    Tavani, A., Longoni, E., Bosetti, C., Maso, L. D., Polesel, J., Montella, M., ... La Vecchia, C. (2006). Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy. European Urology, 50(3), pp. 549-54.
    Tavani A, et al. Intake of Selected Micronutrients and the Risk of Surgically Treated Benign Prostatic Hyperplasia: a Case-control Study From Italy. Eur Urol. 2006;50(3):549-54. PubMed PMID: 16442205.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy. AU - Tavani,Alessandra, AU - Longoni,Elisa, AU - Bosetti,Cristina, AU - Maso,Luigino Dal, AU - Polesel,Jerry, AU - Montella,Maurizio, AU - Ramazzotti,Valerio, AU - Negri,Eva, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, Y1 - 2005/12/28/ PY - 2005/09/09/received PY - 2005/10/18/revised PY - 2005/11/21/accepted PY - 2006/1/31/pubmed PY - 2007/1/30/medline PY - 2006/1/31/entrez SP - 549 EP - 54 JF - European urology JO - Eur. Urol. VL - 50 IS - 3 N2 - OBJECTIVE: To analyze the relationship between surgically treated benign prostatic hyperplasia (BPH) and intake of selected micronutrients. METHODS: A multicentric case-control study was conducted in Italy between 1991 and 2002. Cases were 1369 men with histologically confirmed, surgically treated BPH and controls were 1451 men younger than 75 yr, frequency matched by quinquennium of age and study center, admitted to the hospital for acute nonneoplastic diseases. Information was collected by trained interviewers using a structured validated food-frequency questionnaire. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multiple logistic regression models. RESULTS: The risk of BPH significantly decreased with increasing intake of carotene (OR=0.80 for an increment equal to the difference between the 80th and 20th percentile of intake), alpha-carotene (OR=0.83), beta-carotene (OR=0.82), and cis beta-carotene (OR=0.82) and tended to decrease with the intake of vitamin C (OR=0.89) and iron (OR=0.79). The OR tended to increase with the intake of sodium (OR=1.30) and zinc (OR=1.10). No systematic heterogeneity was observed across strata of age, education, and body mass index. No meaningful associations emerged for other antioxidants, such as folic acid, lycopene, lutein/zeaxanthin, vitamin E, vitamin D, nor for retinol. CONCLUSIONS: Our results suggest a protective effect of carotene on the risk of BPH. The risk tended to decrease also with the intake of vitamin C and iron and tended to increase with the intake of sodium and zinc. Results also indicate that other antioxidants, including folic acid, lycopene, lutein/zeaxanthin, and vitamins D and E, and retinol were not related to the risk for this disease. SN - 0302-2838 UR - https://www.unboundmedicine.com/medline/citation/16442205/Intake_of_selected_micronutrients_and_the_risk_of_surgically_treated_benign_prostatic_hyperplasia:_a_case_control_study_from_Italy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0302-2838(05)00796-7 DB - PRIME DP - Unbound Medicine ER -