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Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial.
Int J Oral Maxillofac Surg. 2006 Jun; 35(6):522-7.IJ

Abstract

The objective is to investigate whether sedation techniques for oral surgery can be improved by combining the use of inhalation of nitrous oxide/oxygen with intravenous Midazolam. Prospective, randomized controlled clinical trial: Patients requiring extractions or surgery were randomly allocated to subgroups receiving either intravenous Midazolam or nitrous oxide/oxygen or a combined technique using nitrous oxide/oxygen and intravenous Midazolam. Safety parameters, amount of sedative agents administered, recovery time and co-operation scores were recorded. Patients receiving the combined sedation technique were initially titrated with 10% nitrous oxide, increasing by increments of 10% up to a maximum of 40% nitrous oxide and 60% oxygen. Midazolam was then titrated (initially 2 mg wait 2 min with increments of 1mg every minute until appropriately sedated) whilst still administering 40% nitrous oxide. When a combined technique of N(2)O/O(2) and Midazolam was used there was a statistically significant reduction in the amount of Midazolam required to achieve effective sedation (P<0.001), an overall significant reduction in recovery time (P<0.001) and a significant improvement in co-operation (P<0.01) and arterial oxygen saturation (P<0.001). This combined technique was found to be safe and reliable, requiring reduced doses of Midazolam and demonstrable improvement in patient recovery and co-operation.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, The Dental School, Framlington Place, Newcastle upon Tyne NE2 4BW, UK. gv@acorndentist.co.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16442264

Citation

Venchard, G R., et al. "Improved Sedation for Oral Surgery By Combining Nitrous Oxide and Intravenous Midazolam: a Randomized, Controlled Trial." International Journal of Oral and Maxillofacial Surgery, vol. 35, no. 6, 2006, pp. 522-7.
Venchard GR, Thomson PJ, Boys R. Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial. Int J Oral Maxillofac Surg. 2006;35(6):522-7.
Venchard, G. R., Thomson, P. J., & Boys, R. (2006). Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial. International Journal of Oral and Maxillofacial Surgery, 35(6), 522-7.
Venchard GR, Thomson PJ, Boys R. Improved Sedation for Oral Surgery By Combining Nitrous Oxide and Intravenous Midazolam: a Randomized, Controlled Trial. Int J Oral Maxillofac Surg. 2006;35(6):522-7. PubMed PMID: 16442264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial. AU - Venchard,G R, AU - Thomson,P J, AU - Boys,R, Y1 - 2006/01/25/ PY - 2005/03/21/received PY - 2005/11/02/revised PY - 2005/11/23/accepted PY - 2006/1/31/pubmed PY - 2006/9/1/medline PY - 2006/1/31/entrez SP - 522 EP - 7 JF - International journal of oral and maxillofacial surgery JO - Int J Oral Maxillofac Surg VL - 35 IS - 6 N2 - The objective is to investigate whether sedation techniques for oral surgery can be improved by combining the use of inhalation of nitrous oxide/oxygen with intravenous Midazolam. Prospective, randomized controlled clinical trial: Patients requiring extractions or surgery were randomly allocated to subgroups receiving either intravenous Midazolam or nitrous oxide/oxygen or a combined technique using nitrous oxide/oxygen and intravenous Midazolam. Safety parameters, amount of sedative agents administered, recovery time and co-operation scores were recorded. Patients receiving the combined sedation technique were initially titrated with 10% nitrous oxide, increasing by increments of 10% up to a maximum of 40% nitrous oxide and 60% oxygen. Midazolam was then titrated (initially 2 mg wait 2 min with increments of 1mg every minute until appropriately sedated) whilst still administering 40% nitrous oxide. When a combined technique of N(2)O/O(2) and Midazolam was used there was a statistically significant reduction in the amount of Midazolam required to achieve effective sedation (P<0.001), an overall significant reduction in recovery time (P<0.001) and a significant improvement in co-operation (P<0.01) and arterial oxygen saturation (P<0.001). This combined technique was found to be safe and reliable, requiring reduced doses of Midazolam and demonstrable improvement in patient recovery and co-operation. SN - 0901-5027 UR - https://www.unboundmedicine.com/medline/citation/16442264/Improved_sedation_for_oral_surgery_by_combining_nitrous_oxide_and_intravenous_Midazolam:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0901-5027(05)00385-1 DB - PRIME DP - Unbound Medicine ER -