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Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence.
Neuropharmacology 2006; 50(7):788-806N

Abstract

The identification of the possible factors that might enhance the risk of developing drug addiction and related motivational disorders is crucial to reduce the prevalence of these problems. Here, we examined in mice whether the exposure to the anabolic-androgenic steroid nandrolone would affect the pharmacological and motivational effects induced by Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of Cannabis sativa. Mice received nandrolone using pre-exposure (during 14days before THC treatment) or co-administration (1h before each THC injection) procedures. Both nandrolone treatments did not modify the acute antinociceptive, hypothermic and hypolocomotor effects of THC or the development of tolerance after chronic THC administration. Nandrolone pre-exposure blocked THC- and food-induced conditioned place preference and increased the somatic manifestations of THC withdrawal precipitated by the CB1 cannabinoid antagonist rimonabant (SR141617A). The aversive effects of THC were not changed by nandrolone. Furthermore, nandrolone pre-exposure attenuated the anxiolytic-like effects of a low dose of THC without altering the anxiogenic-like effects of a high dose in the lit/dark box, open field and elevated plus-maze. Biochemical experiments showed that chronic nandrolone treatment did not modify CB1 receptor binding and GTP-binding protein activation in the caudate-putamen and cerebellum. Taken together, our results suggest that chronic nandrolone treatment alters behavioural responses related to cannabinoid addictive properties.

Authors+Show Affiliations

Laboratori of Neurofarmacologia, Facultat de Ciéncies de la Salut i de la Vida, Universitat Pompeu Fabra, C/Doctor Aiguader 80, 08003 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16443242

Citation

Célérier, Evelyne, et al. "Influence of the Anabolic-androgenic Steroid Nandrolone On Cannabinoid Dependence." Neuropharmacology, vol. 50, no. 7, 2006, pp. 788-806.
Célérier E, Ahdepil T, Wikander H, et al. Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence. Neuropharmacology. 2006;50(7):788-806.
Célérier, E., Ahdepil, T., Wikander, H., Berrendero, F., Nyberg, F., & Maldonado, R. (2006). Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence. Neuropharmacology, 50(7), pp. 788-806.
Célérier E, et al. Influence of the Anabolic-androgenic Steroid Nandrolone On Cannabinoid Dependence. Neuropharmacology. 2006;50(7):788-806. PubMed PMID: 16443242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence. AU - Célérier,Evelyne, AU - Ahdepil,Therese, AU - Wikander,Helena, AU - Berrendero,Fernando, AU - Nyberg,Fred, AU - Maldonado,Rafael, Y1 - 2006/01/27/ PY - 2005/04/08/received PY - 2005/11/29/revised PY - 2005/11/29/accepted PY - 2006/1/31/pubmed PY - 2006/10/7/medline PY - 2006/1/31/entrez SP - 788 EP - 806 JF - Neuropharmacology JO - Neuropharmacology VL - 50 IS - 7 N2 - The identification of the possible factors that might enhance the risk of developing drug addiction and related motivational disorders is crucial to reduce the prevalence of these problems. Here, we examined in mice whether the exposure to the anabolic-androgenic steroid nandrolone would affect the pharmacological and motivational effects induced by Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of Cannabis sativa. Mice received nandrolone using pre-exposure (during 14days before THC treatment) or co-administration (1h before each THC injection) procedures. Both nandrolone treatments did not modify the acute antinociceptive, hypothermic and hypolocomotor effects of THC or the development of tolerance after chronic THC administration. Nandrolone pre-exposure blocked THC- and food-induced conditioned place preference and increased the somatic manifestations of THC withdrawal precipitated by the CB1 cannabinoid antagonist rimonabant (SR141617A). The aversive effects of THC were not changed by nandrolone. Furthermore, nandrolone pre-exposure attenuated the anxiolytic-like effects of a low dose of THC without altering the anxiogenic-like effects of a high dose in the lit/dark box, open field and elevated plus-maze. Biochemical experiments showed that chronic nandrolone treatment did not modify CB1 receptor binding and GTP-binding protein activation in the caudate-putamen and cerebellum. Taken together, our results suggest that chronic nandrolone treatment alters behavioural responses related to cannabinoid addictive properties. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/16443242/Influence_of_the_anabolic_androgenic_steroid_nandrolone_on_cannabinoid_dependence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(05)00405-3 DB - PRIME DP - Unbound Medicine ER -