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Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature.
Gynecol Oncol. 2006 May; 101(2):353-5.GO

Abstract

BACKGROUND

Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin tags caused by a malignancy. We are reporting the first case of ovarian cancer in association with three coexisting cutaneous paraneoplastic dermatosis.

CASE

A 52-year-old female presented with skin manifestation consistent with MAN, TP and the sign of Leser-Tre'lat. Patient underwent extensive work up and was discovered to have stage I, high grade adenocarcinoma of the ovary. Skin manifestations gradually recovered after initiation of chemotherapy.

CONCLUSION

The presence of acanthosis nigricans in conjunction with tripe palms and the sign of Leser-Tre'lat are highly suggestive of an internal malignancy and necessitate an extensive investigation in order to discover the underlying malignancy.

Authors+Show Affiliations

Kebria MM
Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. kebriam@ccf.org
Belinson J
No affiliation info available
Kim R
No affiliation info available
Mekhail TM
No affiliation info available

MeSH

Acanthosis NigricansFemaleHand DermatosesHumansKeratoderma, PalmoplantarKeratosis, SeborrheicMiddle AgedOvarian NeoplasmsParaneoplastic SyndromesSkin Diseases

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16443260

Citation

Kebria, Mehdi M., et al. "Malignant Acanthosis Nigricans, Tripe Palms and the Sign of Leser-Tre'lat, a Hint to the Diagnosis of Early Stage Ovarian Cancer: a Case Report and Review of the Literature." Gynecologic Oncology, vol. 101, no. 2, 2006, pp. 353-5.
Kebria MM, Belinson J, Kim R, et al. Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature. Gynecol Oncol. 2006;101(2):353-5.
Kebria, M. M., Belinson, J., Kim, R., & Mekhail, T. M. (2006). Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature. Gynecologic Oncology, 101(2), 353-5.
Kebria MM, et al. Malignant Acanthosis Nigricans, Tripe Palms and the Sign of Leser-Tre'lat, a Hint to the Diagnosis of Early Stage Ovarian Cancer: a Case Report and Review of the Literature. Gynecol Oncol. 2006;101(2):353-5. PubMed PMID: 16443260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature. AU - Kebria,Mehdi M, AU - Belinson,Jerome, AU - Kim,Robert, AU - Mekhail,Tarek M, Y1 - 2006/01/27/ PY - 2005/11/09/received PY - 2005/12/15/accepted PY - 2006/1/31/pubmed PY - 2006/6/13/medline PY - 2006/1/31/entrez SP - 353 EP - 5 JF - Gynecologic oncology JO - Gynecol Oncol VL - 101 IS - 2 N2 - BACKGROUND: Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. The sign of Leser-Tre'lat is the presence of multiple seborrheic keratoses and scattered skin tags caused by a malignancy. We are reporting the first case of ovarian cancer in association with three coexisting cutaneous paraneoplastic dermatosis. CASE: A 52-year-old female presented with skin manifestation consistent with MAN, TP and the sign of Leser-Tre'lat. Patient underwent extensive work up and was discovered to have stage I, high grade adenocarcinoma of the ovary. Skin manifestations gradually recovered after initiation of chemotherapy. CONCLUSION: The presence of acanthosis nigricans in conjunction with tripe palms and the sign of Leser-Tre'lat are highly suggestive of an internal malignancy and necessitate an extensive investigation in order to discover the underlying malignancy. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/16443260/Malignant_acanthosis_nigricans_tripe_palms_and_the_sign_of_Leser_Tre'lat_a_hint_to_the_diagnosis_of_early_stage_ovarian_cancer:_a_case_report_and_review_of_the_literature_ DB - PRIME DP - Unbound Medicine ER -