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NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats.
Behav Brain Res. 2006 Apr 25; 169(1):120-7.BB

Abstract

In the present study, the effects of post-training intra-dorsal hippocampal (intra-CA1) injection of an N-methyl-D-aspartate (NMDA) receptor agonist and competitive or noncompetitive antagonists, on memory retention of passive avoidance learning was measured in the presence and absence of physostigmine in rats. Intra-CA1 administration of lower doses of the NMDA receptor agonist NMDA (10(-5) and 10(-4) microg/rat) did not affect memory retention, although the higher doses of the drug (10(-3), 10(-2) and 10(-1) microg/rat) increased memory retention. The greatest response was obtained with 10(-1) microg/rat of the drug. The different doses of the competitive NMDA receptor antagonist DL-AP5 (1, 3.2 and 10 microg/rat) and noncompetitive NMDA receptor antagonist MK-801 (0.5, 1 and 2 microg/rat) decreased memory retention in rats dose dependently. Both competitive and noncompetitive NMDA receptor antagonists reduced the effect of NMDA (10(-2) microg/rat). In another series of experiments, intra-CA1 injection of physostigmine (2, 3 and 4 microg/rat) improved memory retention. Post-training co-administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) and physostigmine (1 microg/rat), doses which were ineffective when given alone, significantly improved the retention latency. The competitive and noncompetitive NMDA receptor antagonists, DL-AP5 and MK-801, decreased the effect of physostigmine (2 microg/rat). Atropine decreased memory retention by itself and potentiated the response to DL-AP5 and MK-801. In conclusion, it seems that both NMDA and cholinergic systems not only play a part in the modulation of memory in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. jafarisa@sina.tums.ac.ir

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16443290

Citation

Jafari-Sabet, Majid. "NMDA Receptor Blockers Prevents the Facilitatory Effects of Post-training Intra-dorsal Hippocampal NMDA and Physostigmine On Memory Retention of Passive Avoidance Learning in Rats." Behavioural Brain Research, vol. 169, no. 1, 2006, pp. 120-7.
Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006;169(1):120-7.
Jafari-Sabet, M. (2006). NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behavioural Brain Research, 169(1), 120-7.
Jafari-Sabet M. NMDA Receptor Blockers Prevents the Facilitatory Effects of Post-training Intra-dorsal Hippocampal NMDA and Physostigmine On Memory Retention of Passive Avoidance Learning in Rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. PubMed PMID: 16443290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. A1 - Jafari-Sabet,Majid, Y1 - 2006/01/26/ PY - 2005/11/06/received PY - 2005/12/17/revised PY - 2005/12/23/accepted PY - 2006/1/31/pubmed PY - 2006/4/19/medline PY - 2006/1/31/entrez SP - 120 EP - 7 JF - Behavioural brain research JO - Behav Brain Res VL - 169 IS - 1 N2 - In the present study, the effects of post-training intra-dorsal hippocampal (intra-CA1) injection of an N-methyl-D-aspartate (NMDA) receptor agonist and competitive or noncompetitive antagonists, on memory retention of passive avoidance learning was measured in the presence and absence of physostigmine in rats. Intra-CA1 administration of lower doses of the NMDA receptor agonist NMDA (10(-5) and 10(-4) microg/rat) did not affect memory retention, although the higher doses of the drug (10(-3), 10(-2) and 10(-1) microg/rat) increased memory retention. The greatest response was obtained with 10(-1) microg/rat of the drug. The different doses of the competitive NMDA receptor antagonist DL-AP5 (1, 3.2 and 10 microg/rat) and noncompetitive NMDA receptor antagonist MK-801 (0.5, 1 and 2 microg/rat) decreased memory retention in rats dose dependently. Both competitive and noncompetitive NMDA receptor antagonists reduced the effect of NMDA (10(-2) microg/rat). In another series of experiments, intra-CA1 injection of physostigmine (2, 3 and 4 microg/rat) improved memory retention. Post-training co-administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) and physostigmine (1 microg/rat), doses which were ineffective when given alone, significantly improved the retention latency. The competitive and noncompetitive NMDA receptor antagonists, DL-AP5 and MK-801, decreased the effect of physostigmine (2 microg/rat). Atropine decreased memory retention by itself and potentiated the response to DL-AP5 and MK-801. In conclusion, it seems that both NMDA and cholinergic systems not only play a part in the modulation of memory in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16443290/NMDA_receptor_blockers_prevents_the_facilitatory_effects_of_post_training_intra_dorsal_hippocampal_NMDA_and_physostigmine_on_memory_retention_of_passive_avoidance_learning_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00005-2 DB - PRIME DP - Unbound Medicine ER -