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Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests.

Abstract

The present study was undertaken to investigate the effects of aqueous extract of Glycyrrhiza glabra L. (Family: Fabaceae), popularly known as liquorice, on depression in mice using forced swim test (FST) and tail suspension test (TST). The extract of G. glabra (75, 150, and 300 mg/kg) was administered orally for 7 successive days in separate groups of Swiss young male albino mice. The dose of 150 mg/kg of the extract significantly reduced the immobility times of mice in both FST and TST, without any significant effect on locomotor activity of mice. The efficacy of extract was found to be comparable to that of imipramine (15 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.). Liquorice extract reversed reserpine-induced extension of immobility period of mice in FST and TST. Sulpiride (50 mg/kg i.p.; a selective D2 receptor antagonist) and prazosin (62.5 microg/kg i.p.; an alpha1-adrenoceptor antagonist) significantly attenuated the extract-induced antidepressant-like effect in TST. On the other hand, p-chlorophenylalanine (100 mg/kg i.p.; an inhibitor of serotonin synthesis) did not reverse antidepressant-like effect of liquorice extract. This suggests that antidepressant-like effect of liquorice extract seems to be mediated by increase of brain norepinephrine and dopamine, but not by increase of serotonin. Monoamine oxidase inhibiting effect of liquorice may be contributing favorably to the antidepressant-like activity. Thus, it is concluded that liquorice extract may possess an antidepressant-like effect.

Authors+Show Affiliations

Pharmacology Division, Department Pharmaceutical Sciences, Guru Jambheshwar University, Hisar-125001 (Haryana), India. din_dhingra@rediffmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16443316

Citation

Dhingra, Dinesh, and Amandeep Sharma. "Antidepressant-like Activity of Glycyrrhiza Glabra L. in Mouse Models of Immobility Tests." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 30, no. 3, 2006, pp. 449-54.
Dhingra D, Sharma A. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(3):449-54.
Dhingra, D., & Sharma, A. (2006). Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Progress in Neuro-psychopharmacology & Biological Psychiatry, 30(3), 449-54.
Dhingra D, Sharma A. Antidepressant-like Activity of Glycyrrhiza Glabra L. in Mouse Models of Immobility Tests. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(3):449-54. PubMed PMID: 16443316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. AU - Dhingra,Dinesh, AU - Sharma,Amandeep, Y1 - 2006/01/27/ PY - 2005/11/23/accepted PY - 2006/1/31/pubmed PY - 2006/7/20/medline PY - 2006/1/31/entrez SP - 449 EP - 54 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 30 IS - 3 N2 - The present study was undertaken to investigate the effects of aqueous extract of Glycyrrhiza glabra L. (Family: Fabaceae), popularly known as liquorice, on depression in mice using forced swim test (FST) and tail suspension test (TST). The extract of G. glabra (75, 150, and 300 mg/kg) was administered orally for 7 successive days in separate groups of Swiss young male albino mice. The dose of 150 mg/kg of the extract significantly reduced the immobility times of mice in both FST and TST, without any significant effect on locomotor activity of mice. The efficacy of extract was found to be comparable to that of imipramine (15 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.). Liquorice extract reversed reserpine-induced extension of immobility period of mice in FST and TST. Sulpiride (50 mg/kg i.p.; a selective D2 receptor antagonist) and prazosin (62.5 microg/kg i.p.; an alpha1-adrenoceptor antagonist) significantly attenuated the extract-induced antidepressant-like effect in TST. On the other hand, p-chlorophenylalanine (100 mg/kg i.p.; an inhibitor of serotonin synthesis) did not reverse antidepressant-like effect of liquorice extract. This suggests that antidepressant-like effect of liquorice extract seems to be mediated by increase of brain norepinephrine and dopamine, but not by increase of serotonin. Monoamine oxidase inhibiting effect of liquorice may be contributing favorably to the antidepressant-like activity. Thus, it is concluded that liquorice extract may possess an antidepressant-like effect. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/16443316/Antidepressant_like_activity_of_Glycyrrhiza_glabra_L__in_mouse_models_of_immobility_tests_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(05)00368-4 DB - PRIME DP - Unbound Medicine ER -