Tags

Type your tag names separated by a space and hit enter

Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons.
Neurosci Lett. 2006 May 08; 398(3):253-7.NL

Abstract

The world wide proliferation of mobile phones raises the concern about the health effects of 1800-MHz microwaves on the brain. The present study assesses the effects of microwave exposure on the function of cultured hippocampal neurons of rats using whole cell patch-clamp analysis combined with immunocytochemistry. We showed that chronic exposure (15 min per day for 8 days) to Global System for Mobile Communication (GSM) 1800-MHz microwaves at specific absorption rate (SAR) of 2.4 W/kg induced a selective decrease in the amplitude of alpha-amino-3-hydroxy-5-methyl-4-soxazole propionic acid (AMPA) miniature excitatory postsynaptic currents (mEPSCs), whereas the frequency of AMPA mEPSCs and the amplitude of N-methyl-D-aspartate (NMDA) mEPSCs did not change. Furthermore, the GSM microwave treatment decreased the expression of postsynaptic density 95 (PSD95) in cultured neurons. Our results indicated that 2.4 W/kg GSM 1800-MHz microwaves may reduce excitatory synaptic activity and the number of excitatory synapses in cultured rat hippocampal neurons.

Authors+Show Affiliations

Xu S
Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310031, China.
Ning W
No affiliation info available
Xu Z
No affiliation info available
Zhou S
No affiliation info available
Chiang H
No affiliation info available
Luo J
No affiliation info available

MeSH

AnimalsAnimals, NewbornCells, CulturedExcitatory Postsynaptic PotentialsHippocampusImmunohistochemistryMicrowavesNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSynapses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16443327

Citation

Xu, Shujun, et al. "Chronic Exposure to GSM 1800-MHz Microwaves Reduces Excitatory Synaptic Activity in Cultured Hippocampal Neurons." Neuroscience Letters, vol. 398, no. 3, 2006, pp. 253-7.
Xu S, Ning W, Xu Z, et al. Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons. Neurosci Lett. 2006;398(3):253-7.
Xu, S., Ning, W., Xu, Z., Zhou, S., Chiang, H., & Luo, J. (2006). Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons. Neuroscience Letters, 398(3), 253-7.
Xu S, et al. Chronic Exposure to GSM 1800-MHz Microwaves Reduces Excitatory Synaptic Activity in Cultured Hippocampal Neurons. Neurosci Lett. 2006 May 8;398(3):253-7. PubMed PMID: 16443327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons. AU - Xu,Shujun, AU - Ning,Wei, AU - Xu,Zhengping, AU - Zhou,Suya, AU - Chiang,Huai, AU - Luo,Jianhong, Y1 - 2006/01/27/ PY - 2005/09/27/received PY - 2006/01/02/revised PY - 2006/01/04/accepted PY - 2006/1/31/pubmed PY - 2006/6/9/medline PY - 2006/1/31/entrez SP - 253 EP - 7 JF - Neuroscience letters JO - Neurosci Lett VL - 398 IS - 3 N2 - The world wide proliferation of mobile phones raises the concern about the health effects of 1800-MHz microwaves on the brain. The present study assesses the effects of microwave exposure on the function of cultured hippocampal neurons of rats using whole cell patch-clamp analysis combined with immunocytochemistry. We showed that chronic exposure (15 min per day for 8 days) to Global System for Mobile Communication (GSM) 1800-MHz microwaves at specific absorption rate (SAR) of 2.4 W/kg induced a selective decrease in the amplitude of alpha-amino-3-hydroxy-5-methyl-4-soxazole propionic acid (AMPA) miniature excitatory postsynaptic currents (mEPSCs), whereas the frequency of AMPA mEPSCs and the amplitude of N-methyl-D-aspartate (NMDA) mEPSCs did not change. Furthermore, the GSM microwave treatment decreased the expression of postsynaptic density 95 (PSD95) in cultured neurons. Our results indicated that 2.4 W/kg GSM 1800-MHz microwaves may reduce excitatory synaptic activity and the number of excitatory synapses in cultured rat hippocampal neurons. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16443327/Chronic_exposure_to_GSM_1800_MHz_microwaves_reduces_excitatory_synaptic_activity_in_cultured_hippocampal_neurons_ DB - PRIME DP - Unbound Medicine ER -