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Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae).
J Ethnopharmacol. 2006 Jun 30; 106(2):173-8.JE

Abstract

The chemical composition of total alkaloids from leaves and roots of Guiera senegalensis was investigated. Three beta-carboline alkaloids were purified: in addition to harman and tetrahydroharman, known in roots and leaves, harmalan (dihydroharman) was isolated for the first time from roots of Guiera senegalensis. Guieranone A, a naphthyl butenone, was also purified from leaves and roots. The in vitro antiplasmodial activity and the cytotoxicity of extracts and pure compounds were evaluated. Each total alkaloid extract and beta-carboline alkaloids presented an interesting antiplasmodial activity associated with a low cytotoxicity. Harmalan was less active than harman and tetrahydroharman. Guieranone A showed a strong antiplasmodial activity associated with a high cytotoxicity toward human monocytes. Its cytotoxicity was performed against two cancer cell lines and normal skin fibroblasts in order to study its anticancer potential: guieranone A presented a strong cytotoxicity against each cell strains. Finally, we evaluated the potent synergistic antimalarial interaction between Guiera senegalensis and two plants commonly associated in traditional remedies: Mitragyna inermis and Pavetta crassipes. Three associations evaluated were additive. A synergistic effect was shown between total alkaloids extracted from leaves of Guiera senegalensis and those of Mitragyna inermis. This result justified the traditional use of the plants in combination to treat malaria.

Authors+Show Affiliations

Fiot J
Laboratory of Pharmacognosy, Faculty of Pharmacy, Marseille, France.
Sanon S
No affiliation info available
Azas N
No affiliation info available
Mahiou V
No affiliation info available
Jansen O
No affiliation info available
Angenot L
No affiliation info available
Balansard G
No affiliation info available
Ollivier E
No affiliation info available

MeSH

AlkaloidsAnimalsAntimalarialsButanonesCarbolinesCell SurvivalCombretaceaeDrug SynergismHarmalineHarmineHeLa CellsHumansInhibitory Concentration 50MonocytesNaphthalenesOxindolesParasitic Sensitivity TestsPlant ExtractsPlant LeavesPlant RootsPlasmodium falciparumRubiaceae

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16443341

Citation

Fiot, Julien, et al. "Phytochemical and Pharmacological Study of Roots and Leaves of Guiera Senegalensis J.F. Gmel (Combretaceae)." Journal of Ethnopharmacology, vol. 106, no. 2, 2006, pp. 173-8.
Fiot J, Sanon S, Azas N, et al. Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). J Ethnopharmacol. 2006;106(2):173-8.
Fiot, J., Sanon, S., Azas, N., Mahiou, V., Jansen, O., Angenot, L., Balansard, G., & Ollivier, E. (2006). Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). Journal of Ethnopharmacology, 106(2), 173-8.
Fiot J, et al. Phytochemical and Pharmacological Study of Roots and Leaves of Guiera Senegalensis J.F. Gmel (Combretaceae). J Ethnopharmacol. 2006 Jun 30;106(2):173-8. PubMed PMID: 16443341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). AU - Fiot,Julien, AU - Sanon,Souleymane, AU - Azas,Nadine, AU - Mahiou,Valérie, AU - Jansen,Olivia, AU - Angenot,Luc, AU - Balansard,Guy, AU - Ollivier,Evelyne, Y1 - 2006/01/27/ PY - 2005/02/01/received PY - 2005/11/18/revised PY - 2005/12/15/accepted PY - 2006/1/31/pubmed PY - 2006/12/9/medline PY - 2006/1/31/entrez SP - 173 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 106 IS - 2 N2 - The chemical composition of total alkaloids from leaves and roots of Guiera senegalensis was investigated. Three beta-carboline alkaloids were purified: in addition to harman and tetrahydroharman, known in roots and leaves, harmalan (dihydroharman) was isolated for the first time from roots of Guiera senegalensis. Guieranone A, a naphthyl butenone, was also purified from leaves and roots. The in vitro antiplasmodial activity and the cytotoxicity of extracts and pure compounds were evaluated. Each total alkaloid extract and beta-carboline alkaloids presented an interesting antiplasmodial activity associated with a low cytotoxicity. Harmalan was less active than harman and tetrahydroharman. Guieranone A showed a strong antiplasmodial activity associated with a high cytotoxicity toward human monocytes. Its cytotoxicity was performed against two cancer cell lines and normal skin fibroblasts in order to study its anticancer potential: guieranone A presented a strong cytotoxicity against each cell strains. Finally, we evaluated the potent synergistic antimalarial interaction between Guiera senegalensis and two plants commonly associated in traditional remedies: Mitragyna inermis and Pavetta crassipes. Three associations evaluated were additive. A synergistic effect was shown between total alkaloids extracted from leaves of Guiera senegalensis and those of Mitragyna inermis. This result justified the traditional use of the plants in combination to treat malaria. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16443341/Phytochemical_and_pharmacological_study_of_roots_and_leaves_of_Guiera_senegalensis_J_F__Gmel__Combretaceae__ DB - PRIME DP - Unbound Medicine ER -