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Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration.
J Nutr Biochem. 2006 May; 17(5):291-306.JN

Abstract

Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. These therapeutic properties have long been attributed to the catechins' antioxidant and free radical scavenging effects. Emerging evidence has shown that catechins and their metabolites have many additional mechanisms of action by affecting numerous sites, potentiating endogenous antioxidants and eliciting dual actions during oxidative stress, ischemia and inflammation. Catechins have proven to modulate apoptosis at various points in the sequence, including altering expression of anti- and proapoptotic genes. Their anti-inflammatory effects are activated through a variety of different mechanisms, including modulation of nitric oxide synthase isoforms. Catechins' actions of attenuating oxidative stress and the inflammatory response may, in part, account for their confirmed neuroprotective capabilities following cerebral ischemia. The versatility of the mechanisms of action of catechins increases their therapeutic potential as interventions for numerous clinical disorders. However, more epidemiological and clinical studies need to be undertaken for their efficacy to be fully elucidated.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, University of Otago, Dunedin, P.O. Box 913, Dunedin, New Zealand.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16443357

Citation

Sutherland, Brad A., et al. "Mechanisms of Action of Green Tea Catechins, With a Focus On Ischemia-induced Neurodegeneration." The Journal of Nutritional Biochemistry, vol. 17, no. 5, 2006, pp. 291-306.
Sutherland BA, Rahman RM, Appleton I. Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J Nutr Biochem. 2006;17(5):291-306.
Sutherland, B. A., Rahman, R. M., & Appleton, I. (2006). Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. The Journal of Nutritional Biochemistry, 17(5), 291-306.
Sutherland BA, Rahman RM, Appleton I. Mechanisms of Action of Green Tea Catechins, With a Focus On Ischemia-induced Neurodegeneration. J Nutr Biochem. 2006;17(5):291-306. PubMed PMID: 16443357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. AU - Sutherland,Brad A, AU - Rahman,Rosanna M A, AU - Appleton,Ian, Y1 - 2005/11/08/ PY - 2005/09/24/received PY - 2005/10/11/accepted PY - 2006/1/31/pubmed PY - 2006/6/6/medline PY - 2006/1/31/entrez SP - 291 EP - 306 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 17 IS - 5 N2 - Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. These therapeutic properties have long been attributed to the catechins' antioxidant and free radical scavenging effects. Emerging evidence has shown that catechins and their metabolites have many additional mechanisms of action by affecting numerous sites, potentiating endogenous antioxidants and eliciting dual actions during oxidative stress, ischemia and inflammation. Catechins have proven to modulate apoptosis at various points in the sequence, including altering expression of anti- and proapoptotic genes. Their anti-inflammatory effects are activated through a variety of different mechanisms, including modulation of nitric oxide synthase isoforms. Catechins' actions of attenuating oxidative stress and the inflammatory response may, in part, account for their confirmed neuroprotective capabilities following cerebral ischemia. The versatility of the mechanisms of action of catechins increases their therapeutic potential as interventions for numerous clinical disorders. However, more epidemiological and clinical studies need to be undertaken for their efficacy to be fully elucidated. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/16443357/Mechanisms_of_action_of_green_tea_catechins_with_a_focus_on_ischemia_induced_neurodegeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(05)00269-X DB - PRIME DP - Unbound Medicine ER -