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Coffee consumption and incidence of colorectal cancer in two prospective cohort studies of Swedish women and men.
Am J Epidemiol 2006; 163(7):638-44AJ

Abstract

Investigators have reported an inverse association between coffee consumption and risk of colorectal cancer in several case-control studies, but prospective studies, most of them involving small numbers of cases, have not supported such a relation. In this analysis, the authors prospectively examined the association of coffee consumption with colorectal cancer risk among participants from two population-based cohort studies: 61,433 women in the Swedish Mammography Cohort and 45,306 men in the Cohort of Swedish Men. Information about coffee consumption was obtained from food frequency questionnaires in 1987-1990 and 1997 for women and in 1997 for men. The authors used Cox proportional hazards modeling for cohort-specific multivariate analyses, and results were pooled using random-effects models. During 1,240,597 person-years of follow-up, 1,279 incident cases of colorectal cancer were diagnosed. Coffee consumption was not associated with risk of colorectal cancer, colon cancer, or rectal cancer in either women or men. For both cohorts combined, the multivariate rate ratio for colorectal cancer for each additional cup of coffee per day was 1.00 (95% confidence interval: 0.97, 1.04). The associations were not modified by colorectal cancer risk factors. The findings from these two large prospective cohort studies do not support the hypothesis that coffee consumption lowers the risk of colorectal cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16443798

Citation

Larsson, Susanna C., et al. "Coffee Consumption and Incidence of Colorectal Cancer in Two Prospective Cohort Studies of Swedish Women and Men." American Journal of Epidemiology, vol. 163, no. 7, 2006, pp. 638-44.
Larsson SC, Bergkvist L, Giovannucci E, et al. Coffee consumption and incidence of colorectal cancer in two prospective cohort studies of Swedish women and men. Am J Epidemiol. 2006;163(7):638-44.
Larsson, S. C., Bergkvist, L., Giovannucci, E., & Wolk, A. (2006). Coffee consumption and incidence of colorectal cancer in two prospective cohort studies of Swedish women and men. American Journal of Epidemiology, 163(7), pp. 638-44.
Larsson SC, et al. Coffee Consumption and Incidence of Colorectal Cancer in Two Prospective Cohort Studies of Swedish Women and Men. Am J Epidemiol. 2006 Apr 1;163(7):638-44. PubMed PMID: 16443798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and incidence of colorectal cancer in two prospective cohort studies of Swedish women and men. AU - Larsson,Susanna C, AU - Bergkvist,Leif, AU - Giovannucci,Edward, AU - Wolk,Alicja, Y1 - 2006/01/27/ PY - 2006/1/31/pubmed PY - 2006/5/5/medline PY - 2006/1/31/entrez SP - 638 EP - 44 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 163 IS - 7 N2 - Investigators have reported an inverse association between coffee consumption and risk of colorectal cancer in several case-control studies, but prospective studies, most of them involving small numbers of cases, have not supported such a relation. In this analysis, the authors prospectively examined the association of coffee consumption with colorectal cancer risk among participants from two population-based cohort studies: 61,433 women in the Swedish Mammography Cohort and 45,306 men in the Cohort of Swedish Men. Information about coffee consumption was obtained from food frequency questionnaires in 1987-1990 and 1997 for women and in 1997 for men. The authors used Cox proportional hazards modeling for cohort-specific multivariate analyses, and results were pooled using random-effects models. During 1,240,597 person-years of follow-up, 1,279 incident cases of colorectal cancer were diagnosed. Coffee consumption was not associated with risk of colorectal cancer, colon cancer, or rectal cancer in either women or men. For both cohorts combined, the multivariate rate ratio for colorectal cancer for each additional cup of coffee per day was 1.00 (95% confidence interval: 0.97, 1.04). The associations were not modified by colorectal cancer risk factors. The findings from these two large prospective cohort studies do not support the hypothesis that coffee consumption lowers the risk of colorectal cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16443798/Coffee_consumption_and_incidence_of_colorectal_cancer_in_two_prospective_cohort_studies_of_Swedish_women_and_men_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj067 DB - PRIME DP - Unbound Medicine ER -