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Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients.
Clin Exp Pharmacol Physiol. 2006 Jan-Feb; 33(1-2):114-8.CE

Abstract

1. Treatment with haemodialysis and continuous ambulatory peritoneal dialysis (CAPD) presents different pathophysiological profiles and it has been suggested that clinical outcome in chronic renal failure may depend on the mode of dialysis. The transport of L-arginine, a precursor of nitric oxide, into blood cells is increased in uraemic patients on haemodialysis. The present study was designed to investigate L-arginine transport into red blood cells (RBC) in uraemic patients not yet on dialysis and on CAPD therapy. 2. Eleven uraemic patients not yet on dialysis and 17 on CAPD were included in the study. L-Arginine transport into RBC and plasma and RBC amino acid profiles were analysed in these sets of patients. 3. L-Arginine transport via system y(+), but not y(+)L, into RBC, was significantly increased in undialysed uraemic patients (459 +/- 40 micromol/L per cell per h) and CAPD patients (539 +/- 61 micromol/L per cell per h) compared with controls (251 +/- 39 micromol/L per cell per h). High-pressure liquid chromatography measurements demonstrated low levels of plasma L-arginine in uraemic patients both on CAPD (54 +/- 3 micromol/L) and not yet on dialysis (80 +/- 6 micromol/L) compared with control subjects (146 +/- 14 micromol/L). 4. Our findings provide the first evidence that uraemic patients not yet on dialysis and on CAPD present with an activation of L-arginine transport via system y(+) into RBC associated with reduced plasma levels of L-arginine.

Authors+Show Affiliations

Departamento de Farmacologia e Psicobiologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16445709

Citation

Brunini, T M C., et al. "Activation of L-arginine Transport in Undialysed Chronic Renal Failure and Continuous Ambulatory Peritoneal Dialysis Patients." Clinical and Experimental Pharmacology & Physiology, vol. 33, no. 1-2, 2006, pp. 114-8.
Brunini TM, Roberts NB, Yaqoob MM, et al. Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients. Clin Exp Pharmacol Physiol. 2006;33(1-2):114-8.
Brunini, T. M., Roberts, N. B., Yaqoob, M. M., Ellory, J. C., Mann, G. E., & Mendes Ribeiro, A. C. (2006). Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients. Clinical and Experimental Pharmacology & Physiology, 33(1-2), 114-8.
Brunini TM, et al. Activation of L-arginine Transport in Undialysed Chronic Renal Failure and Continuous Ambulatory Peritoneal Dialysis Patients. Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):114-8. PubMed PMID: 16445709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients. AU - Brunini,T M C, AU - Roberts,N B, AU - Yaqoob,M M, AU - Ellory,J C, AU - Mann,G E, AU - Mendes Ribeiro,A C, PY - 2006/2/1/pubmed PY - 2006/4/14/medline PY - 2006/2/1/entrez SP - 114 EP - 8 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 33 IS - 1-2 N2 - 1. Treatment with haemodialysis and continuous ambulatory peritoneal dialysis (CAPD) presents different pathophysiological profiles and it has been suggested that clinical outcome in chronic renal failure may depend on the mode of dialysis. The transport of L-arginine, a precursor of nitric oxide, into blood cells is increased in uraemic patients on haemodialysis. The present study was designed to investigate L-arginine transport into red blood cells (RBC) in uraemic patients not yet on dialysis and on CAPD therapy. 2. Eleven uraemic patients not yet on dialysis and 17 on CAPD were included in the study. L-Arginine transport into RBC and plasma and RBC amino acid profiles were analysed in these sets of patients. 3. L-Arginine transport via system y(+), but not y(+)L, into RBC, was significantly increased in undialysed uraemic patients (459 +/- 40 micromol/L per cell per h) and CAPD patients (539 +/- 61 micromol/L per cell per h) compared with controls (251 +/- 39 micromol/L per cell per h). High-pressure liquid chromatography measurements demonstrated low levels of plasma L-arginine in uraemic patients both on CAPD (54 +/- 3 micromol/L) and not yet on dialysis (80 +/- 6 micromol/L) compared with control subjects (146 +/- 14 micromol/L). 4. Our findings provide the first evidence that uraemic patients not yet on dialysis and on CAPD present with an activation of L-arginine transport via system y(+) into RBC associated with reduced plasma levels of L-arginine. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/16445709/Activation_of_L_arginine_transport_in_undialysed_chronic_renal_failure_and_continuous_ambulatory_peritoneal_dialysis_patients_ DB - PRIME DP - Unbound Medicine ER -