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Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications.
Life Sci. 2006 Mar 27; 78(18):2073-80.LS

Abstract

Can drinking several cups of green tea a day keep the doctor away? This certainly seems so, given the popularity of this practice in East Asian culture and the increased interest in green tea in the Western world. Several epidemiological studies have shown beneficial effects of green tea in cancer, cardiovascular, and neurological diseases. The health benefits associated with green tea consumption have also been corroborated in animal studies of cancer chemoprevention, hypercholesterolemia, artherosclerosis, Parkinson's disease, Alzheimer's disease, and other aging-related disorders. However, the use of green tea as a cancer chemopreventive or for other health benefits has been confounded by the low oral bioavailability of its active polyphenolic catechins, particularly epigallocatechin-3-gallate (EGCG), the most active catechin. This review summarizes the purported beneficial effects of green tea and EGCG in various animal models of human diseases. Dose-related differences in the effects of EGCG in cancer versus neurodegenerative and cardiovascular diseases, as well as discrepancies between doses used in in vitro studies and achievable plasma understanding of the in vivo effects of green tea catechins in humans, before the use of green tea is widely adopted as health-promoting measure.

Authors+Show Affiliations

Drug Discovery Program, Biosciences Division, SRI International, Menlo Park, CA 94025, USA. nurulain.zaveri@sri.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16445946

Citation

Zaveri, Nurulain T.. "Green Tea and Its Polyphenolic Catechins: Medicinal Uses in Cancer and Noncancer Applications." Life Sciences, vol. 78, no. 18, 2006, pp. 2073-80.
Zaveri NT. Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 2006;78(18):2073-80.
Zaveri, N. T. (2006). Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sciences, 78(18), 2073-80.
Zaveri NT. Green Tea and Its Polyphenolic Catechins: Medicinal Uses in Cancer and Noncancer Applications. Life Sci. 2006 Mar 27;78(18):2073-80. PubMed PMID: 16445946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. A1 - Zaveri,Nurulain T, Y1 - 2006/01/30/ PY - 2005/04/06/received PY - 2005/12/07/accepted PY - 2006/2/1/pubmed PY - 2006/4/21/medline PY - 2006/2/1/entrez SP - 2073 EP - 80 JF - Life sciences JO - Life Sci VL - 78 IS - 18 N2 - Can drinking several cups of green tea a day keep the doctor away? This certainly seems so, given the popularity of this practice in East Asian culture and the increased interest in green tea in the Western world. Several epidemiological studies have shown beneficial effects of green tea in cancer, cardiovascular, and neurological diseases. The health benefits associated with green tea consumption have also been corroborated in animal studies of cancer chemoprevention, hypercholesterolemia, artherosclerosis, Parkinson's disease, Alzheimer's disease, and other aging-related disorders. However, the use of green tea as a cancer chemopreventive or for other health benefits has been confounded by the low oral bioavailability of its active polyphenolic catechins, particularly epigallocatechin-3-gallate (EGCG), the most active catechin. This review summarizes the purported beneficial effects of green tea and EGCG in various animal models of human diseases. Dose-related differences in the effects of EGCG in cancer versus neurodegenerative and cardiovascular diseases, as well as discrepancies between doses used in in vitro studies and achievable plasma understanding of the in vivo effects of green tea catechins in humans, before the use of green tea is widely adopted as health-promoting measure. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/16445946/Green_tea_and_its_polyphenolic_catechins:_medicinal_uses_in_cancer_and_noncancer_applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(05)01241-5 DB - PRIME DP - Unbound Medicine ER -