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Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease.
J Cell Physiol 2006; 208(1):39-46JC

Abstract

The diagnosis of AD is still largely based on exclusion criteria of secondary causes and other forms of dementia with similar clinical pictures, than the diagnostic accuracy of AD is low. Improved methods of early diagnosis are needed, particularly because drugs treatment is more effective in the early stages of the disease. Recent research focused the attention to biochemical diagnostic markers (biomarkers) and according to the proposal of a consensus group on biomarkers, three candidate CSF markers reflecting the pathological AD processes, have recently been identified: total tau protein (t-tau), amyloid beta(1-42) protein (A beta42), and tau protein phosphorylated at AD-specific epitopes (p-tau). Several articles report reduced CSF levels of A beta42 and increased CSF levels of t-tau and p-tau in AD; the sensitivity and specificity of these data are able for discrimination of AD patients from controls. However, the specificity for other dementias is low. According to the literature analysis reported in the present review, we can conclude that the combination of the CSF markers and their ratios may significantly increase the specificity and the accuracy of AD diagnosis.

Authors+Show Affiliations

Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16447254

Citation

Formichi, Patrizia, et al. "Cerebrospinal Fluid Tau, a Beta, and Phosphorylated Tau Protein for the Diagnosis of Alzheimer's Disease." Journal of Cellular Physiology, vol. 208, no. 1, 2006, pp. 39-46.
Formichi P, Battisti C, Radi E, et al. Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease. J Cell Physiol. 2006;208(1):39-46.
Formichi, P., Battisti, C., Radi, E., & Federico, A. (2006). Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease. Journal of Cellular Physiology, 208(1), pp. 39-46.
Formichi P, et al. Cerebrospinal Fluid Tau, a Beta, and Phosphorylated Tau Protein for the Diagnosis of Alzheimer's Disease. J Cell Physiol. 2006;208(1):39-46. PubMed PMID: 16447254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease. AU - Formichi,Patrizia, AU - Battisti,Carla, AU - Radi,Elena, AU - Federico,Antonio, PY - 2006/2/1/pubmed PY - 2006/7/27/medline PY - 2006/2/1/entrez SP - 39 EP - 46 JF - Journal of cellular physiology JO - J. Cell. Physiol. VL - 208 IS - 1 N2 - The diagnosis of AD is still largely based on exclusion criteria of secondary causes and other forms of dementia with similar clinical pictures, than the diagnostic accuracy of AD is low. Improved methods of early diagnosis are needed, particularly because drugs treatment is more effective in the early stages of the disease. Recent research focused the attention to biochemical diagnostic markers (biomarkers) and according to the proposal of a consensus group on biomarkers, three candidate CSF markers reflecting the pathological AD processes, have recently been identified: total tau protein (t-tau), amyloid beta(1-42) protein (A beta42), and tau protein phosphorylated at AD-specific epitopes (p-tau). Several articles report reduced CSF levels of A beta42 and increased CSF levels of t-tau and p-tau in AD; the sensitivity and specificity of these data are able for discrimination of AD patients from controls. However, the specificity for other dementias is low. According to the literature analysis reported in the present review, we can conclude that the combination of the CSF markers and their ratios may significantly increase the specificity and the accuracy of AD diagnosis. SN - 0021-9541 UR - https://www.unboundmedicine.com/medline/citation/16447254/Cerebrospinal_fluid_tau_A_beta_and_phosphorylated_tau_protein_for_the_diagnosis_of_Alzheimer's_disease_ L2 - https://doi.org/10.1002/jcp.20602 DB - PRIME DP - Unbound Medicine ER -