Tags

Type your tag names separated by a space and hit enter

Incidence of psychiatric disorder in offspring at high and low risk for depression.
J Am Acad Child Adolesc Psychiatry. 1992 Jul; 31(4):640-8.JA

Abstract

First onsets (incidence) of suicide attempts and DSM-III psychiatric disorders, including major depression, any anxiety disorder, conduct disorder, or substance abuse were determined in a 2-year longitudinal study of 174 offspring at high and low risk for major depression. All of the suicide attempts, the first onsets of major depression, and anxiety disorders were in offspring of depressed parents. Compared with asymptomatic offspring, offspring with subclinical manifestations of major depression, conduct disorder, and substance abuse at the initial interview were significantly more likely to become incident cases of the same disorder over the next 2 years. Either conduct disorder or substance abuse at initial interview were highly predictive of first onset of each other, but not of any other disorders 2 years later. Family risk factors (such as poor marital adjustment, parent-child discord, low cohesion, and affectionless control) at initial interview were associated with increased incidence of substance abuse, or conduct disorder, but not major depression or anxiety disorder. Combining both retrospective and prospective data, the overall suicide attempt rate was 7.8% in the offspring of depressed parents as compared with 1.4% in the offspring of nondepressed parents. By age 20, over 50% of the offspring of depressed patients reported a major depression.

Authors+Show Affiliations

College of Physicians and Surgeons, Columbia University, New York, NY.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1644726

Citation

Weissman, M M., et al. "Incidence of Psychiatric Disorder in Offspring at High and Low Risk for Depression." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 31, no. 4, 1992, pp. 640-8.
Weissman MM, Fendrich M, Warner V, et al. Incidence of psychiatric disorder in offspring at high and low risk for depression. J Am Acad Child Adolesc Psychiatry. 1992;31(4):640-8.
Weissman, M. M., Fendrich, M., Warner, V., & Wickramaratne, P. (1992). Incidence of psychiatric disorder in offspring at high and low risk for depression. Journal of the American Academy of Child and Adolescent Psychiatry, 31(4), 640-8.
Weissman MM, et al. Incidence of Psychiatric Disorder in Offspring at High and Low Risk for Depression. J Am Acad Child Adolesc Psychiatry. 1992;31(4):640-8. PubMed PMID: 1644726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of psychiatric disorder in offspring at high and low risk for depression. AU - Weissman,M M, AU - Fendrich,M, AU - Warner,V, AU - Wickramaratne,P, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 640 EP - 8 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 31 IS - 4 N2 - First onsets (incidence) of suicide attempts and DSM-III psychiatric disorders, including major depression, any anxiety disorder, conduct disorder, or substance abuse were determined in a 2-year longitudinal study of 174 offspring at high and low risk for major depression. All of the suicide attempts, the first onsets of major depression, and anxiety disorders were in offspring of depressed parents. Compared with asymptomatic offspring, offspring with subclinical manifestations of major depression, conduct disorder, and substance abuse at the initial interview were significantly more likely to become incident cases of the same disorder over the next 2 years. Either conduct disorder or substance abuse at initial interview were highly predictive of first onset of each other, but not of any other disorders 2 years later. Family risk factors (such as poor marital adjustment, parent-child discord, low cohesion, and affectionless control) at initial interview were associated with increased incidence of substance abuse, or conduct disorder, but not major depression or anxiety disorder. Combining both retrospective and prospective data, the overall suicide attempt rate was 7.8% in the offspring of depressed parents as compared with 1.4% in the offspring of nondepressed parents. By age 20, over 50% of the offspring of depressed patients reported a major depression. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/1644726/Incidence_of_psychiatric_disorder_in_offspring_at_high_and_low_risk_for_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)64079-X DB - PRIME DP - Unbound Medicine ER -