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[Effect of Coeloglossum. viride var. bracteatum extract on oxidation injury in sub-acute senescent model mice].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Dec; 27(6):729-33.ZY

Abstract

OBJECTIVE

To study the anti-aging effects of Coeloglossum. viride (L) Hartm. var. bracteatum (Willd) Richter extract (CE) on senescent model mice induced by D-galactose and sodium nitrite.

METHODS

After one week of accommodation, 60 female NIH mice were divided into six groups with 10 mice in each group: normal control group, aging model group, Piracetam (positive control) group [300 mg/ (kg x d)], and CE reatment groups [2.5, 5, and 10 mg/ (kg x d)]. Mice in aging model group, Piracetam group, and CE treatment group were consecutively intraperitoneally injected with D-galactose [120 mg/ (kg x d)] and sodium nitrite [90 mg/ (kg x d)] for 60 days. From day 47, mice in Piracetam group and CE treatment group were po given Piracetam 300 mg/ (kg x d) or CE 2.5, 5, and 10 mg/ (kg x d). Mice in normal control group and aging model group were po given saline. The drug administration lasted for 14 days. Water maze test was performed to evaluate the learning and memory function in the mice. The activity of superoxide dismutase (SOD), the content of malondialdehyde (MDA), and the activities of adenosinetriphosphatase (ATPase), and monoamine-oxidase (MAO) in brain tissue were measured.

RESULTS

The latencies in water maze test in aging model group mice were significantly longer than in normal control group (P < 0.01, P < 0.05), and the number of errors increased (P < 0.05). In aging model group mice, the activities of SOD, Na+K(+)-ATPase, and Ca2+Mg(2+)-ATPase decreased (P < 0.01, P < 0.05), while the content of MDA and the activities of MAO-A and MAO-B increased (P < 0.01). Piracetam [300 mg/ (kg x d), po] and CE [2.5, 5, 10 mg/ (kg x d), po] ameliorated the above changes in aging model mice.

CONCLUSION

CE may improve the memory dysfunction induced by consecutive injection of D-galactose and sodium nitrite,and has nootropic and antiaging effects.

Authors+Show Affiliations

Department of Pharmacology, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China.No affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

16447647

Citation

Zhang, Dan, and Jian-jun Zhang. "[Effect of Coeloglossum. Viride Var. Bracteatum Extract On Oxidation Injury in Sub-acute Senescent Model Mice]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 27, no. 6, 2005, pp. 729-33.
Zhang D, Zhang JJ. [Effect of Coeloglossum. viride var. bracteatum extract on oxidation injury in sub-acute senescent model mice]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005;27(6):729-33.
Zhang, D., & Zhang, J. J. (2005). [Effect of Coeloglossum. viride var. bracteatum extract on oxidation injury in sub-acute senescent model mice]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 27(6), 729-33.
Zhang D, Zhang JJ. [Effect of Coeloglossum. Viride Var. Bracteatum Extract On Oxidation Injury in Sub-acute Senescent Model Mice]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005;27(6):729-33. PubMed PMID: 16447647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of Coeloglossum. viride var. bracteatum extract on oxidation injury in sub-acute senescent model mice]. AU - Zhang,Dan, AU - Zhang,Jian-jun, PY - 2006/2/2/pubmed PY - 2007/3/28/medline PY - 2006/2/2/entrez SP - 729 EP - 33 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 27 IS - 6 N2 - OBJECTIVE: To study the anti-aging effects of Coeloglossum. viride (L) Hartm. var. bracteatum (Willd) Richter extract (CE) on senescent model mice induced by D-galactose and sodium nitrite. METHODS: After one week of accommodation, 60 female NIH mice were divided into six groups with 10 mice in each group: normal control group, aging model group, Piracetam (positive control) group [300 mg/ (kg x d)], and CE reatment groups [2.5, 5, and 10 mg/ (kg x d)]. Mice in aging model group, Piracetam group, and CE treatment group were consecutively intraperitoneally injected with D-galactose [120 mg/ (kg x d)] and sodium nitrite [90 mg/ (kg x d)] for 60 days. From day 47, mice in Piracetam group and CE treatment group were po given Piracetam 300 mg/ (kg x d) or CE 2.5, 5, and 10 mg/ (kg x d). Mice in normal control group and aging model group were po given saline. The drug administration lasted for 14 days. Water maze test was performed to evaluate the learning and memory function in the mice. The activity of superoxide dismutase (SOD), the content of malondialdehyde (MDA), and the activities of adenosinetriphosphatase (ATPase), and monoamine-oxidase (MAO) in brain tissue were measured. RESULTS: The latencies in water maze test in aging model group mice were significantly longer than in normal control group (P < 0.01, P < 0.05), and the number of errors increased (P < 0.05). In aging model group mice, the activities of SOD, Na+K(+)-ATPase, and Ca2+Mg(2+)-ATPase decreased (P < 0.01, P < 0.05), while the content of MDA and the activities of MAO-A and MAO-B increased (P < 0.01). Piracetam [300 mg/ (kg x d), po] and CE [2.5, 5, 10 mg/ (kg x d), po] ameliorated the above changes in aging model mice. CONCLUSION: CE may improve the memory dysfunction induced by consecutive injection of D-galactose and sodium nitrite,and has nootropic and antiaging effects. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/16447647/[Effect_of_Coeloglossum__viride_var__bracteatum_extract_on_oxidation_injury_in_sub_acute_senescent_model_mice]_ L2 - https://medlineplus.gov/learningdisabilities.html DB - PRIME DP - Unbound Medicine ER -